{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:55:58Z","timestamp":1769925358764,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T00:00:00Z","timestamp":1457308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Control of sympathetic hyperactivity is pivotal for treatment of heart failure (HF) in patients with coronary artery disease (CAD). Our earlier studies demonstrated that the auricular pulsed electrical stimulation of the vagus nerve (VNS) beneficially affected condition of CAD patients with HF. The aim of our study was to evaluate changes in heart rate (HR) and the levels of heat shock proteins in peripheral blood lymphocytes in patients with CAD in the course of VNS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study comprised 70 individuals aged 50\u201368 years with chronic coronary insufficiency, severe left ventricular dysfunction, and NYHA functional class (FC) III\u2013IV HF. Main group included 63 patients who received VNS course (group 1). Control patients (n = 7) received sham therapy (group 2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to the results of 6\u2010minute walk test and 24\u2010hour ECG monitoring, administration of VNS improved clinical condition of 58 of 63 patients, decreased HF FC, and attenuated HR. Clinical condition in sham therapy group did not change. Immunoenzyme method demonstrated that hsp70 and hsp60 contents in peripheral blood lymphocyte lysate increased by 58% and 48% (P &lt; 0.05), respectively, in patients who initially had HR &lt; 80 bpm. The hsp70 level significantly increased and hsp60 level remained unchanged in patients with initial HR &gt; 80 bpm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Correction of autonomous nervous status by VNS attenuated HR and improved functional state of the heart in CAD patients. Cardiotropic effect of VNS was the most pronounced in patients with preserved endogenous stress\u2010limiting systems associated with hsp60 and\/or hsp70.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12349","type":"journal-article","created":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T10:06:36Z","timestamp":1457345196000},"page":"548-556","source":"Crossref","is-referenced-by-count":21,"title":["Nonpharmacological Correction of Hypersympatheticotonia in Patients with Chronic Coronary Insufficiency and Severe Left Ventricular Dysfunction"],"prefix":"10.1111","volume":"21","author":[{"given":"Sergey A.","family":"Afanasiev","sequence":"first","affiliation":[{"name":"Federal State Budgetary Scientific Institution \u201cResearch Institute for Cardiology,\u201d  Tomsk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena N.","family":"Pavliukova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution \u201cResearch 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