{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:07:45Z","timestamp":1781086065770,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T00:00:00Z","timestamp":1471910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30570746"],"award-info":[{"award-number":["30570746"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Background<\/jats:title>Only implantable cardioverter defibrillators (ICD<\/jats:styled-content>) have been proven to prevent sudden cardiac death (SCD<\/jats:styled-content>) in patients with Brugada syndrome (BrS). However, ICD<\/jats:styled-content> discharge, whether appropriate or inappropriate, leads to impaired quality of life and even increases rehospitalization. Quinidine might prevent the recurrence of ventricular arrhythmia (VA<\/jats:styled-content>); however, the effect of low\u2010dose quinidine for preventing spontaneous arrhythmias remains less clear.<\/jats:p><\/jats:sec>Methods<\/jats:title>In our cardiology center, 10 confirmed patients with BrS (all men, mean age 38.7 \u00b1 6.72 years) who underwent appropriate ICD<\/jats:styled-content> shocks due to recurrent VA<\/jats:styled-content>s were treated with quinidine (\u2264200 mg\/day) and followed regularly.<\/jats:p><\/jats:sec>Results<\/jats:title>All the patients underwent ICD<\/jats:styled-content> shocks due to ventricular tachycardia (VT<\/jats:styled-content>)\/ventricular fibrillation (VF<\/jats:styled-content>) before taking quinidine. A 24\u2010hour distribution of VT<\/jats:styled-content>\/VF<\/jats:styled-content> demonstrated that most of the events occurred in the sleeping time from 22:00 to 8:00. Quinidine prevented recurrence of VA<\/jats:styled-content>s in nine patients. The other one patient took quinidine discontinuously because of anxiety suffered from less episodes of VA<\/jats:styled-content>, and after psychological guidance, he took quinidine 200 mg\/day and experienced no VA<\/jats:styled-content> episodes from then on. In our series, only one patient suffered leukopenia related to quinidine. No other side effect was observed.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Quinidine with a very low dose (\u2264200 mg\/day) well controlled VT<\/jats:styled-content>\/VF<\/jats:styled-content> recurrence for a long\u2010term period in Chinese patients with BrS. Administration (at 21:00) according to the circadian distribution of VT<\/jats:styled-content>\/VF<\/jats:styled-content> episodes might increase the efficiency and improve the patient's tolerance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12375","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T10:03:21Z","timestamp":1471946601000},"source":"Crossref","is-referenced-by-count":16,"title":["Low\u2010Dose Quinidine Effectively Reduced Shocks in Brugada Syndrome Patients with an Implantable Cardioverter Defibrillator: A Chinese Case Series Report"],"prefix":"10.1111","volume":"22","author":[{"given":"Tongtong","family":"Shen","sequence":"first","affiliation":[{"name":"Cardiovascular Department The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Nanjing Benq 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