{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T17:44:23Z","timestamp":1769103863937,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The clinical significance of electrocardiogram in the assessment of patients with idiopathic dilated cardiomyopathy (<jats:styled-content style=\"fixed-case\">IDCM<\/jats:styled-content>) is currently unknown. The aim of this study was to determine the feasibility of recording serial changes in Sokolow\u2013Lyon voltage (\u2206%<jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\u2010voltage) in one year to estimate left ventricular reverse remodeling (<jats:styled-content style=\"fixed-case\">LVRR<\/jats:styled-content>) and predict a prognosis of <jats:styled-content style=\"fixed-case\">IDCM<\/jats:styled-content> patients under tailored medical therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010eight consecutive patients with mild symptoms (52.1\u00a0\u00b1\u00a013\u00a0years old; 69% men; <jats:styled-content style=\"fixed-case\">NYHA I<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>; 33\/29\/6\/0) underwent electrocardiography and echocardiography at baseline and 12\u00a0month follow\u2010up (follow\u2010up period: 3.9\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LVRR<\/jats:styled-content> was observed in 30 patients (44.1%). The \u2206%<jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\u2010voltage was significantly lower in the <jats:styled-content style=\"fixed-case\">LVRR<\/jats:styled-content> group (<jats:styled-content style=\"fixed-case\">LVRR<\/jats:styled-content>; \u221226.9%, non\u2010<jats:styled-content style=\"fixed-case\">LVRR<\/jats:styled-content>: \u22129.2%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Univariate analysis showed that \u2206%<jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\u2010voltage correlated with \u2206%<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> end\u2010diastolic diameter (r\u00a0=\u00a0.634, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), and with \u2206%<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> ejection fraction and \u2206%<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> mass index (r\u00a0=\u00a0\u2212.412, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001; r\u00a0=\u00a0.429, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001 respectively). Using receiver operating characteristic curve analysis for the estimation of <jats:styled-content style=\"fixed-case\">LVRR<\/jats:styled-content>, \u2206%<jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> of \u221214.7% showed optimal sensitivity (63.2%) and specificity (83.3%) (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\u00a0=\u00a00.775, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). The composite endpoints of cardiac death (<jats:italic>n<\/jats:italic>\u00a0=\u00a00), hospitalization for advanced heart failure (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) and fatal arrhythmia (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) were observed in 13 patients during the follow\u2010up period. Kaplan<jats:bold>\u2013<\/jats:bold>Meier analysis showed significantly higher event\u2010free rate in patients of the low \u2206%<jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\u2010voltage group (&lt;\u221214.7%) (83%) than those of the high group (66%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study showed that decrease in Sokolow\u2013Lyon voltage is associated with improvement in cardiac function and favorable prognosis in <jats:styled-content style=\"fixed-case\">IDCM<\/jats:styled-content> patients on medical therapy, suggesting that this index is a feasible marker for response to treatment of <jats:styled-content style=\"fixed-case\">IDCM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12431","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T13:31:47Z","timestamp":1486128707000},"source":"Crossref","is-referenced-by-count":6,"title":["Sokolow\u2010Lyon voltage is suitable for monitoring improvement in cardiac function and prognosis of patients with idiopathic dilated cardiomyopathy"],"prefix":"10.1111","volume":"22","author":[{"given":"Kenji","family":"Fukaya","sequence":"first","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyosuke","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Department of Clinical Laboratory; Nagoya University Hospital  Nagoya 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