{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:06:06Z","timestamp":1791014766072,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T00:00:00Z","timestamp":1495065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Background<\/jats:title>Although the majority of Class III<\/jats:styled-content> congestive heart failure (HF) patients treated with cardiac resynchronization therapy (CRT<\/jats:styled-content>) show a clinical benefit, up to 40% of patients do not respond to CRT<\/jats:styled-content>. This paper reports the design of the MultiPoint Pacing (MPP<\/jats:styled-content>) trial, a prospective, randomized, double\u2010blind, controlled study to evaluate the safety and efficacy of CRT<\/jats:styled-content> using MPP<\/jats:styled-content> compared to standard biventricular (Bi\u2010V) pacing.<\/jats:p><\/jats:sec>Methods<\/jats:title>A maximum of 506 patients with a standard CRT<\/jats:styled-content>\u2010D indication will be enrolled at up to 50 US<\/jats:styled-content> centers. All patients will be implanted with a CRT<\/jats:styled-content>\u2010D system (Quartet LV<\/jats:styled-content> lead Model 1458Q with a Quadra CRT<\/jats:styled-content>\u2010D, Abbott) that can deliver both MPP<\/jats:styled-content> and Bi\u2010V pacing. Standard Bi\u2010V pacing will be activated at implant. At 3\u00a0months postimplant, patients in whom the echocardiographic parameters during MPP<\/jats:styled-content> are equal or better than during Bi\u2010V pacing are randomized (1:1) to either an MPP<\/jats:styled-content> or Bi\u2010V arm.<\/jats:p><\/jats:sec>Results<\/jats:title>The primary safety endpoint is freedom from system\u2010related complications at 9\u00a0months. Each patient's response to CRT<\/jats:styled-content> will be evaluated using a heart\u2010failure clinical composite score, consisting of a change in NYHA<\/jats:styled-content> functional class, patient global assessment score, HF events, and cardiovascular death. The primary efficacy endpoint is the proportion of responders in the MPP<\/jats:styled-content> arm compared with the Bi\u2010V arm between 3 and 9\u00a0months.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This trial seeks to evaluate whether MPP<\/jats:styled-content> via a single quadripolar LV<\/jats:styled-content> lead improves hemodynamic and clinical responses to CRT<\/jats:styled-content>, both in clinical responders and nonresponders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12448","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T10:53:31Z","timestamp":1495104811000},"source":"Crossref","is-referenced-by-count":10,"title":["Rationale and design of a randomized trial to assess the safety and efficacy of MultiPoint Pacing (MPP) in cardiac resynchronization therapy: The MPP Trial"],"prefix":"10.1111","volume":"22","author":[{"given":"Gery","family":"Tomassoni","sequence":"first","affiliation":[{"name":"Baptist Health Lexington Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"James","family":"Baker","sequence":"additional","affiliation":[{"name":"Saint Thomas Research Institute Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Corbisiero","sequence":"additional","affiliation":[{"name":"Deborah Heart and Lung Browns Mills NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Love","sequence":"additional","affiliation":[{"name":"NYU Langone Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Martin","sequence":"additional","affiliation":[{"name":"Lahey Hospital and Medical Center \u2010 Cardiology Burlington MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sheppard","sequence":"additional","affiliation":[{"name":"The Heart Institute St. Petersburg FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth J.","family":"Worley","sequence":"additional","affiliation":[{"name":"Lancaster Heart Foundation Lancaster PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9826-552X","authenticated-orcid":false,"given":"Kwangdeok","family":"Lee","sequence":"additional","affiliation":[{"name":"Abbott Plano TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Niazi","sequence":"additional","affiliation":[{"name":"Aurora Cardiovascular Services Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the MPP Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,18]]},"reference":[{"issue":"346","key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1056\/NEJMoa013168","article-title":"Cardiac resynchronization in chronic heart failure","volume":"13","author":"Abraham W. 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