{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:26:45Z","timestamp":1753878405306,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Optimization of coronary sinus (<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>) lead position to the latest activated left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) area is important to increase cardiac resynchronization therapy (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>) response. We aimed to detect the relationship between coronary sinus lead delay index (<jats:styled-content style=\"fixed-case\">CSDI<\/jats:styled-content>) and echocardiographic, electrocardiographic response to <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively included 137 consecutive patients with heart failure (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>) diagnosis, QRS\u00a0\u2265\u00a0120\u00a0ms, left bundle branch block (<jats:styled-content style=\"fixed-case\">LBBB<\/jats:styled-content>), New York Heart Association score (<jats:styled-content style=\"fixed-case\">NYHA<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> LV<\/jats:styled-content> ejection fraction (<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>) &lt;35% and scheduled for <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> (84 male, 53 female; mean age 65.1\u00a0\u00b1\u00a010.1\u00a0years). Echocardiographic <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> response was defined as \u226515% reduction in <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> end\u2010systolic volume (<jats:styled-content style=\"fixed-case\">LVESV<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> lead sensing delay was calculated as the time interval from the onset of surface <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> wave to the onset of depolarization wave recorded from the <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> lead by using the <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> pacing lead as a bipolar electrode. <jats:styled-content style=\"fixed-case\">CSDI<\/jats:styled-content> was calculated by dividing the <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> lead sensing delay by the <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LVESV<\/jats:styled-content> reduction was associated with baseline <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> width (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.257, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002), <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> narrowing (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.396, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), <jats:styled-content style=\"fixed-case\">CSDI<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.357, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), and <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\u2010pro<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.213, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.022) in bivariate analysis. In logistic regression analysis, <jats:styled-content style=\"fixed-case\">CSDI<\/jats:styled-content> was found to be only independent parameter for predicting significant <jats:styled-content style=\"fixed-case\">LVESV<\/jats:styled-content> reduction (Beta\u00a0=\u00a00.318, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). <jats:styled-content style=\"fixed-case\">CSDI<\/jats:styled-content> was also found to be significantly associated with <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> increase (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.244, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004) and <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> narrowing (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.178, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CSDI<\/jats:styled-content> may be used as a marker to predict the favorable response to <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>. It may be useful to integrate <jats:styled-content style=\"fixed-case\">CSDI<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> implantation procedure in order to minimize nonresponders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12454","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T05:55:23Z","timestamp":1496123723000},"source":"Crossref","is-referenced-by-count":2,"title":["Coronary sinus lead delay index for optimization of coronary sinus lead placement"],"prefix":"10.1111","volume":"23","author":[{"given":"Mevl\u00fct","family":"Ko\u00e7","sequence":"first","affiliation":[{"name":"Department of Cardiology Adana Health Practices and Research Center Health Sciences University  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5065-3283","authenticated-orcid":false,"given":"Onur","family":"Kaypakli","sequence":"additional","affiliation":[{"name":"Department of Cardiology Adana Health Practices and Research Center Health Sciences University  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6khan","family":"G\u00f6z\u00fcb\u00fcy\u00fck","sequence":"additional","affiliation":[{"name":"Department of Cardiology Adana Health Practices and Research Center Health Sciences University  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Durmus","family":"Y\u0131ld\u0131ray \u015eahin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Adana Health Practices and Research Center Health Sciences University  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq389"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm034"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12348"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc5001.102229"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12101"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.07.025"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur250"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr329"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.014324"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.986943"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.12.030"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2013.11.010"},{"key":"e_1_2_5_17_1","first-page":"21","article-title":"Implantation of left ventricular lead guided by electrical mapping in a heart failure patient receiving cardiac resynchronization therapy","volume":"16","author":"Liang Y. 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