{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:44:50Z","timestamp":1762623890558,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:00:00Z","timestamp":1497484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["T32 NR007088","F31 NR015196"],"award-info":[{"award-number":["T32 NR007088","F31 NR015196"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RO1HL69753"],"award-info":[{"award-number":["RO1HL69753"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cheyne\u2010Stokes respiration (<jats:styled-content style=\"fixed-case\">CSR<\/jats:styled-content>) has been investigated primarily in outpatients with heart failure. In this study we compare <jats:styled-content style=\"fixed-case\">CSR<\/jats:styled-content> and periodic breathing (<jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>) between healthy and cardiac groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared <jats:styled-content style=\"fixed-case\">CSR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>, measured during 24\u00a0hr of continuous 12\u2010lead electrocardiographic (<jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content>) Holter recording, in a group of 90 hospitalized patients presenting to the emergency department with symptoms suggestive of acute coronary syndrome (<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>) to a group of 100 healthy ambulatory participants. We also examined <jats:styled-content style=\"fixed-case\">CSR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> in the 90 patients presenting with <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> symptoms, divided into a group of 39 (43%) with confirmed <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>, and 51 (57%) with a cardiac diagnosis but non\u2010<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>. Super<jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> software was used to derive respiration and then calculate <jats:styled-content style=\"fixed-case\">CSR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> episodes from the <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> Holter data. Regression analyses were used to analyze the data. We hypothesized Super<jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> software would differentiate between the groups by detecting less <jats:styled-content style=\"fixed-case\">CSR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> in the healthy group than the group of patients presenting to the emergency department with <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hospitalized patients with suspected <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> had 7.3 times more <jats:styled-content style=\"fixed-case\">CSR<\/jats:styled-content> episodes and 1.6 times more <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> episodes than healthy ambulatory participants. Patients with confirmed <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> had 6.0 times more <jats:styled-content style=\"fixed-case\">CSR<\/jats:styled-content> episodes and 1.3 times more <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> episodes than cardiac non\u2010<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Continuous 12\u2010lead <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> derived <jats:styled-content style=\"fixed-case\">CSR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> appear to differentiate between healthy participants and hospitalized patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12462","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T11:32:30Z","timestamp":1497526350000},"source":"Crossref","is-referenced-by-count":8,"title":["<scp>ECG<\/scp>\u2010derived Cheyne\u2010Stokes respiration and periodic breathing in healthy and hospitalized populations"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2190-5824","authenticated-orcid":false,"given":"Adelita","family":"Tinoco","sequence":"first","affiliation":[{"name":"University of California, San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara J.","family":"Drew","sequence":"additional","affiliation":[{"name":"University of California, San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[{"name":"University of California, San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mortara","sequence":"additional","affiliation":[{"name":"University of California, San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce A.","family":"Cooper","sequence":"additional","affiliation":[{"name":"University of California, San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele M.","family":"Pelter","sequence":"additional","affiliation":[{"name":"University of California, San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1016\/j.rppneu.2011.07.004"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1378\/chest.07-0121"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1097\/ALN.0b013e31816d83e4"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.5665\/sleep.2078"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1056\/NEJMoa1506459"},{"key":"e_1_2_6_7_1","first-page":"313","article-title":"Suspicion of obstructive sleep apnea by Berlin Questionnaire predicts events in patients with acute coronary syndrome","volume":"95","author":"De Jesus E. 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