{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:44:49Z","timestamp":1790030689418,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:00:00Z","timestamp":1496793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"KAKEN"},{"name":"Grants-in-Aid for Young Scientific Research","award":["23790880"],"award-info":[{"award-number":["23790880"]}]},{"name":"Tokai University School of Medicine Research Aid"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Carbon\u2010ion irradiation of rabbit hearts has improved left ventricular conduction abnormalities through upregulation of gap junctions. However, to date, there has been no investigation on the effect of carbon\u2010ion irradiation on electrophysiological properties in human. We investigated this effect in patients with mediastinum extra\u2010cardiac cancer treated with carbon\u2010ion radiotherapy that included irradiating the heart.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>In April\u2013December 2009, eight patients were prospectively enrolled (including two male, aged 72.5\u00a0\u00b1\u00a013.0\u00a0years). They were treated with 44\u201372 Gray equivalent (GyE), with their hearts exposed to 1.3\u201319.1 GyE. High\u2010resolution ambulatory electrocardiography was performed before and after radiotherapy to investigate arrhythmic events, late potentials (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>s), and heart rate variability. Five patients had pre\u2010existing premature ventricular contraction (<jats:styled-content style=\"fixed-case\">PVC<\/jats:styled-content>)\/atrial contraction (<jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>) or paroxysmal atrial fibrillation (<jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content>)\/<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>; after irradiation, this improved in four patients with <jats:styled-content style=\"fixed-case\">PVC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> and did not deteriorate in one patient with <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>. Ventricular <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> findings did not deteriorate and improved in one patient. In eight cases with available atrial <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> findings, there was no deterioration, and two patients showed improvements. The low frequency\/high frequency ratio of heart rate variability improved or did not deteriorate in the six patients who received radiation exposure to the bilateral stellate ganglions. During the five\u2010year follow\u2010up for the prognosis, six of the eight patients died because of cancer; there was no history of hospitalization for cardiac events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although this preliminary study has several limitations, carbon\u2010ion beam irradiation to the heart is not immediately cardiotoxic and demonstrates consistent signals of arrhythmia reduction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12468","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T10:32:45Z","timestamp":1496831565000},"source":"Crossref","is-referenced-by-count":6,"title":["Changes in arrhythmogenic properties and five\u2010year prognosis after carbon\u2010ion radiotherapy in patients with mediastinum cancer"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4562-7141","authenticated-orcid":false,"given":"Mari","family":"Amino","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Tokai University  Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Tokai University  Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiyoshi","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Tokai University  Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine  Nagoya 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