{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:23:29Z","timestamp":1760217809142,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:00:00Z","timestamp":1496793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chordate Medical AB, Sweden"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Kinetic oscillation stimulation in the nasal cavity (KOS) has been shown to have positive symptomatic effects in subjects with non\u2010allergic rhinitis and in patients with migraine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To evaluate the effect of KOS on autonomic function, we assessed heart rate variability (HRV) in this small exploratory study in 12 healthy subjects. KOS treatment was performed using a minimally invasive system with a single\u2010use catheter inserted into the nasal cavity. During treatment, the tip was inflated and oscillated with a mean pressure of 95 millibar and amplitude of the oscillations of 100 millibar at a frequency of 68\u00a0Hz. Treatment was given for 15\u00a0minutes sequentially on each side. Heart rate variability was assessed during five 30\u2010minutes periods before, during and immediately after KOS treatment and 3.5\u00a0hours thereafter. KOS resulted in a substantial reduction of HRV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As compared to baseline recorded during 30\u00a0minutes preceding treatment, VLF was reduced by 65%, LF by 55%, the ratio LF\/HF by 44%, with somewhat smaller observed effects in the time domain; SDNN and RMSDD were reduced by of 36% and 18%, respectively. Heart rate remained stable during treatment with minimal mean changes from 68\u00a0\u00b1\u00a07\u00a0bpm before to 68\u00a0\u00b1\u00a09 and 69\u00a0\u00b1\u00a09\u00a0bpm during and after treatment. Reduction of HRV parameters was consistently seen in all subjects, with rapid onset and return towards baseline values during post\u2010treatment observation periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>KOS has an effect on the autonomic balance with pronounced heart\u2010rate independent reduction on HRV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12474","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T10:36:39Z","timestamp":1496831799000},"source":"Crossref","is-referenced-by-count":6,"title":["Effects of intranasal kinetic oscillation stimulation on heart rate variability"],"prefix":"10.1111","volume":"23","author":[{"given":"Markus","family":"Jerling","sequence":"first","affiliation":[{"name":"Markus Jerling Consulting AB  Bromma Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Cygankiewicz","sequence":"additional","affiliation":[{"name":"Department of Electrocardiology Medical University of Lodz  Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil","family":"Al\u2010Tawil","sequence":"additional","affiliation":[{"name":"Karolinska Trial Alliance Phase I Unit Karolinska University Hospital  Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5008-5052","authenticated-orcid":false,"given":"Borje","family":"Darpo","sequence":"additional","affiliation":[{"name":"iCardiac Technologies, Inc.  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