{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:17:18Z","timestamp":1753877838542,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T00:00:00Z","timestamp":1512000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>Timothy syndrome (<jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>) is a multisystemic disease that occurs because of a mutation in <jats:italic><jats:styled-content style=\"fixed-case\">CACN<\/jats:styled-content>1C<\/jats:italic> gene and is characterized by prolonged <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content> interval. Mexiletine is a Class 1B antiarrhythmic drug that causes the disappearance of T\u2010wave alternans by shortening <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c and peak\u2010to\u2010end of the T wave. It may block the development of torsades de pointes in a prolonged <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>. This study presented the case of a patient diagnosed with <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> and had a cardiac arrest history, prolonged <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>, and T\u2010wave alternans. After mexiletine treatment, the <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval shortened and T\u2010wave alternans disappeared. Such a case has rarely been seen in the literature, and hence considered rare. This case presentation was of particular importance because it highlighted the use of mexiletine besides an initial beta\u2010blocker treatment in the cases with <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/anec.12522","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T09:22:43Z","timestamp":1512033763000},"source":"Crossref","is-referenced-by-count":6,"title":["A case report: Is mexiletine usage effective in the shortening of <scp>QTC<\/scp> interval and improving the T\u2010wave alternans in Timothy syndrome?"],"prefix":"10.1111","volume":"23","author":[{"given":"Gulhan","family":"Tunca Sahin","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital Istanbul Saglik Bilimleri University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-0435","authenticated-orcid":false,"given":"Yakup","family":"Ergul","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital Istanbul Saglik Bilimleri University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2015.05.008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5152\/AnatolJCardiol.2015.6315"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000092"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.04.024"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-011-0358-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960130509"},{"key":"e_1_2_7_8_1","unstructured":"Napolitano C. 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