{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:33:01Z","timestamp":1788186781421,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,24]],"date-time":"2018-02-24T00:00:00Z","timestamp":1519430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002655","name":"Beckman Coulter Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007478","name":"Cardiovascular Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004362","name":"Schweizerische Herzstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004830","name":"Siemens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004830","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007478","name":"Cardiovascular Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008401","name":"Stiftung Professor Dr. Max Clo\u00ebtta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"\n Background<\/jats:title>\n \n The cardiac electrical biomarker (\n CEB<\/jats:styled-content>\n ) is a novel electrocardiographic (\n ECG<\/jats:styled-content>\n ) marker quantifying the dipolar activity of the heart with higher levels indicating myocardial injury.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We prospectively enrolled 1097 patients presenting with suspected non\u2010\n ST<\/jats:styled-content>\n \u2010elevation myocardial infarction (\n NSTEMI<\/jats:styled-content>\n ) to the emergency department (\n ED<\/jats:styled-content>\n ). Digital 12\u2010lead\n ECG<\/jats:styled-content>\n s were recorded at presentation and the\n CEB<\/jats:styled-content>\n values were calculated in a blinded fashion. The final diagnosis was adjudicated by two independent cardiologists. The prognostic endpoint was all\u2010cause mortality during 2\u00a0years of follow\u2010up.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n NSTEMI<\/jats:styled-content>\n was the final diagnosis in 14% of patients.\n CEB<\/jats:styled-content>\n levels were higher in patients with\n NSTEMI<\/jats:styled-content>\n compared to other causes of chest pain (median 44 (\n IQR<\/jats:styled-content>\n 21\u201398) vs. 30 (\n IQR<\/jats:styled-content>\n 16\u201361),\n p<\/jats:italic>\n \u00a0<\u00a0.001). A weak but significant correlation between levels of high\u2010sensitivity cardiac troponin T (hs\u2010\n cTnT<\/jats:styled-content>\n ) at admission to the\n ED<\/jats:styled-content>\n and the\n CEB<\/jats:styled-content>\n was found (\n r<\/jats:italic>\n \u00a0=\u00a0.23,\n p<\/jats:italic>\n \u00a0<\u00a0.001). The use of the\n CEB<\/jats:styled-content>\n in addition to conventional\n ECG<\/jats:styled-content>\n criteria improved the diagnostic accuracy for the diagnosis of\n NSTEMI<\/jats:styled-content>\n as quantified by the area under the receiver operating characteristics curve from 0.66 to 0.71 (\n p<\/jats:italic>\n \u00a0<\u00a0.001) and the sensitivity improved from 43% to 79% (\n p<\/jats:italic>\n \u00a0<\u00a0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In conclusion, the\n CEB<\/jats:styled-content>\n , an\n ECG<\/jats:styled-content>\n marker of myocardial injury, significantly improves the accuracy and sensitivity of the\n ECG<\/jats:styled-content>\n for the diagnosis of\n NSTEMI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/anec.12538","type":"journal-article","created":{"date-parts":[[2018,2,24]],"date-time":"2018-02-24T02:13:17Z","timestamp":1519438397000},"source":"Crossref","is-referenced-by-count":9,"title":["Diagnostic value of the cardiac electrical biomarker, a novel\n ECG<\/scp>\n marker indicating myocardial injury, in patients with symptoms suggestive of non\u2010\n ST<\/scp>\n \u2010elevation myocardial infarction"],"prefix":"10.1111","volume":"23","author":[{"given":"Ivo","family":"Strebel","sequence":"first","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Twerenbold","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"},{"name":"University Heart Center Hamburg Clinic for General and Interventional Cardiology Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Boeddinghaus","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Ab\u00e4cherli","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"},{"name":"Institute for Medical Engineering Lucerne University of Applied Sciences and Arts Horw Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rubini Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Wildi","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Grimm","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Puelacher","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Badertscher","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid","family":"Sabti","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Breitenb\u00fccher","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Jann","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Selman","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"du Fay de Lavallaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Schaerli","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Nestelberger","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Stelzig","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Freese","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Osswald","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-8415","authenticated-orcid":false,"given":"Tobias","family":"Reichlin","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital Basel University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.01.151"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2015.08.014"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31828478ac"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.182881"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2015.249508"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":"Early diagnosis of acute myocardial infarction in patients with mild elevations of cardiac troponin","volume":"1","author":"Boeddinghaus J.","year":"2017","journal-title":"Clinical Research in Cardiology"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-1-200301070-00012-w1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.132654"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu188"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.100867"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr236"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1896"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903515"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2011-0540"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0560"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_8_19_1","first-page":"1","article-title":"National hospital ambulatory medical care survey: 2005 emergency department summary","volume":"386","author":"Nawar E. W.","year":"2007","journal-title":"Advanced Data"},{"key":"e_1_2_8_20_1","unstructured":"R Core Team. (2016).R: A Language and Environment for Statistical Computing [Internet]. Vienna Austria: R Foundation for Statistical Computing; 2016. Retrieved fromhttps:\/\/www.R-project.org\/"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900428"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.01.076"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.023937"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2012.3698"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr033"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv320"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-13-162"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12109"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2014.12.029"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs215"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/HPC.0000000000000006"},{"key":"e_1_2_8_32_1","unstructured":"Therneau T. M.(2015).A Package for Survival Analysis in S [Internet]. 2015. Retrieved fromhttp:\/\/CRAN.R-project.org\/package=survival"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3294-8"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31826e1058"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.187397"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs154"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365510701666031"}],"container-title":["Annals of Noninvasive Electrocardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanec.12538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.12538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T22:34:27Z","timestamp":1694990067000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/anec.12538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,24]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/anec.12538"],"URL":"https:\/\/doi.org\/10.1111\/anec.12538","archive":["Portico"],"relation":{},"ISSN":["1082-720X","1542-474X"],"issn-type":[{"value":"1082-720X","type":"print"},{"value":"1542-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,24]]},"article-number":"e12538"}}