{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:52:20Z","timestamp":1758477140235,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Background<\/jats:title>The prognostic value of T\u2010wave morphology parameters in coronary artery disease in the current treatment era is not well established.<\/jats:p><\/jats:sec>Methods<\/jats:title>The Innovation to reduce Cardiovascular Complications of Diabetes at the Intersection (ARTEMIS<\/jats:styled-content>) study included 1,946 patients with angiographically verified coronary artery disease (CAD<\/jats:styled-content>). The study patients underwent thorough examinations including 12\u2010lead digital electrocardiogram (ECG<\/jats:styled-content>) at baseline.<\/jats:p><\/jats:sec>Results<\/jats:title>During a follow\u2010up period of 73\u00a0\u00b1\u00a022\u00a0months, a total of 201 (10.3%) patients died. Of the study patients, 95 (4.9%) experienced cardiac death (CD<\/jats:styled-content>) consisting of 44 (2.3%) sudden cardiac deaths (SCD<\/jats:styled-content>) and 51 (2.6%) nonsudden cardiac deaths (NSCD<\/jats:styled-content>), and 106 (5.4%) patients experienced noncardiac death (NCD<\/jats:styled-content>). T\u2010wave morphology dispersion (TMD<\/jats:styled-content>), T\u2010wave area dispersion (TWAD<\/jats:styled-content>), and total cosine R\u2010to\u2010T (TCRT<\/jats:styled-content>) had a significant association with CD<\/jats:styled-content> even after adjustment with relevant clinical risk markers in the Cox regression analysis (multivariate HR<\/jats:styled-content>s: 1.015, 95% CI<\/jats:styled-content> 1.007\u20131.023, p<\/jats:italic>\u00a0=\u00a0.0003; 0.474, 95% CI<\/jats:styled-content> 0.305\u20130.737, p<\/jats:italic>\u00a0=\u00a0.0009; 0.598, 95% CI<\/jats:styled-content> 0.412\u20130.866, p<\/jats:italic>\u00a0=\u00a0.006, respectively). When including these parameters to the clinical risk model for CD<\/jats:styled-content>, the C\u2010index increased from 0.810 to 0.823 improving the discrimination significantly (integrated discrimination index [IDI<\/jats:styled-content>]\u00a0=\u00a00.0118, 95% CI<\/jats:styled-content> 0.0028\u20130.0208, p<\/jats:italic>\u00a0=\u00a0.01). These parameters were more closely associated with NSCD<\/jats:styled-content> (multivariate p<\/jats:italic>\u2010values from .016 to .001) than with SCD<\/jats:styled-content> (univariate\/multivariate p<\/jats:italic>\u2010values for TMD<\/jats:styled-content> .015\/.197 and for TCRT<\/jats:styled-content> .012\/.43).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>T\u2010wave morphology parameters describing repolarization heterogeneity improve the predictive power of the clinical risk model for CD<\/jats:styled-content> in patients with CAD<\/jats:styled-content> in the current treatment era.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12539","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T09:12:57Z","timestamp":1519722777000},"source":"Crossref","is-referenced-by-count":9,"title":["Prognostic value of T\u2010wave morphology parameters in coronary artery disease in current treatment era"],"prefix":"10.1111","volume":"23","author":[{"given":"Joni M.","family":"Pirkola","sequence":"first","affiliation":[{"name":"Research Unit of Internal Medicine Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maija","family":"Konttinen","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuomas V.","family":"Kentt\u00e4","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6166-5589","authenticated-orcid":false,"given":"Lauri T. A.","family":"Holmstr\u00f6m","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Juhani","family":"Junttila","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olavi H.","family":"Ukkola","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki V.","family":"Huikuri","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1157-3985","authenticated-orcid":false,"given":"Juha S.","family":"Perki\u00f6m\u00e4ki","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02513351"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.03.036"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur393"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2016.05.009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.023838"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9572(01)00464-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.959734"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00203-3"},{"key":"e_1_2_6_11_1","first-page":"S209","article-title":"Dispersion of T\u2010wave area in left precordial leads predicts sudden cardiac death in standard 12\u2010lead electrocardiogram","volume":"12","author":"Kentt\u00e4 T.","year":"2015","journal-title":"Heart Rhythm"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.11.035"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.02.030"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)10190-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.08.052"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487316679522"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000356"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00962.2001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.06.017"},{"key":"e_1_2_6_21_1","unstructured":"WHO. 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