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Our aim was to study the association between the phenotype and ventricular repolarization dynamics in HCM<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>HCM<\/jats:styled-content> patients with either the MYBPC<\/jats:styled-content>3<\/jats:italic>\u2010Q1061X or TPM<\/jats:styled-content>1<\/jats:italic>\u2010D175N mutation (n\u00a0=\u00a0<\/jats:italic>46) and control subjects without mutation and hypertrophy (n<\/jats:italic>\u00a0=\u00a035) were studied with 24\u2010hr ambulatory ECG<\/jats:styled-content> recordings by measuring time intervals of rate\u2010adapted QT<\/jats:styled-content> (QT<\/jats:styled-content>e), maximal QT<\/jats:styled-content>, and T\u2010wave apex to wave end (TPE<\/jats:styled-content>) intervals and the QT<\/jats:styled-content>e\/RR<\/jats:styled-content> slope. Findings were correlated to specified echocardiographic and cardiac magnetic resonance imaging (CMRI<\/jats:styled-content>) findings.<\/jats:p><\/jats:sec>Results<\/jats:title>Rate\u2010adapted QT<\/jats:styled-content>e interval was progressively longer in HCM<\/jats:styled-content> patients with decreasing heart rates compared to control subjects (p<\/jats:italic>\u00a0=\u00a00.020). The degree of hypertrophy correlated with measured QT<\/jats:styled-content>e values. HCM<\/jats:styled-content> patients with maximal wall thickness higher than the mean (20.6\u00a0mm) had longer maximum QT<\/jats:styled-content>e and median TPE<\/jats:styled-content> intervals compared to control subjects and HCM<\/jats:styled-content> patients with milder hypertrophy (p<\/jats:italic>\u00a0<\u00a00.001 and p<\/jats:italic>\u00a0=\u00a00.014, respectively). HCM<\/jats:styled-content> patients with late gadolinium enhancement (LGE<\/jats:styled-content>) on CMRI<\/jats:styled-content> had steeper QT<\/jats:styled-content>e\/RR<\/jats:styled-content> slopes compared to HCM<\/jats:styled-content> patients without LGE<\/jats:styled-content> and control subjects (p<\/jats:italic>\u00a0=\u00a00.044 and p<\/jats:italic>\u00a0=\u00a00.001, respectively). LGE<\/jats:styled-content> was an independent predictor of QT<\/jats:styled-content>e\/RR<\/jats:styled-content> slope (p<\/jats:italic>\u00a0=\u00a00.023, B<\/jats:italic>\u00a0=\u00a00.043).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Dynamics of ventricular repolarization in HCM<\/jats:styled-content> are affected by hypertrophy and fibrosis. LGE<\/jats:styled-content> may confer an independent effect on QT<\/jats:styled-content> dynamics which may increase the arrhythmogenic potential in HCM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12582","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T07:04:26Z","timestamp":1530687866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Fibrosis and wall thickness affect ventricular repolarization dynamics in hypertrophic cardiomyopathy"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5409-3300","authenticated-orcid":false,"given":"Mikko","family":"Jalanko","sequence":"first","affiliation":[{"name":"Department of Cardiology, Heart and Lung Center Helsinki University Hospital and University of Helsinki Helsinki 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