{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:52:20Z","timestamp":1784371940259,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,12]],"date-time":"2018-08-12T00:00:00Z","timestamp":1534032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patient prognosis in type 1 myotonic dystrophy (DM1) is very poor. Annual 24\u2010hour holter ECG monitoring is recommended but its relevance is debated. Main objective was to determine whether holter ECG parameters could predict global death in DM1 patients and secondarily to assess whether they could predict cardiovascular events and sudden cardiac death, to compare DM1 patients and healthy controls, and to assess their evolution in DM1 over a 5\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included genetically confirmed DM1. Primary endpoint was global death. Secondary endpoints were labeled \u201csudden cardiac death\u201d which was a composite of sudden cardiac death, aborted sudden cardiac death, implantable cardioverter defibrillator therapy, sustained ventricular tachycardia, atrioventricular block grade 3, pause &gt;3\u00a0s; and \u201ccardiovascular events\u201d which was a composite of all\u2010cause mortality, pacemaker or cardioverter defibrillator implantation, sustained ventricular tachycardia, supraventricular tachycardia, hospitalization for acute cardiac cause and heart failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven patients (22 women, 40\u00a0\u00b1\u00a013\u00a0years old) were included. Three (7%) DM1 patients died, 9 (19%) experienced \"sudden cardiac death\" endpoint and 21 (45%) experienced \"cardiovascular event\" endpoint during mean follow\u2010up of 95\u00a0\u00b1\u00a022\u00a0months. None of holter ECG parameters were discriminant to predict death or secondary endpoints. Compared to healthy controls, DM1 patients had higher SDNN and LF\/HF ratio. Finally, heart rate variability parameters remained stable over a mean interval of 61\u00a0\u00b1\u00a015\u00a0months excepting pNN50 which decreased significantly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results suggest that annually\u2010repeated holter ECG in DM1 is not useful for stratifying risk of sudden death and cardiovascular outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12587","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T05:53:34Z","timestamp":1534139614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Twenty\u2010four\u2010hour ambulatory ECG monitoring relevancy in myotonic dystrophy type 1 follow\u2010up: Prognostic value and heart rate variability evolution"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-6464","authenticated-orcid":false,"given":"Alexandre","family":"Gamet","sequence":"first","affiliation":[{"name":"Department of Cardiology CHU Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Degand","sequence":"additional","affiliation":[{"name":"Department of Cardiology CHU Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Le Gal","sequence":"additional","affiliation":[{"name":"Department of Cardiology CHU Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bidegain","sequence":"additional","affiliation":[{"name":"Department of Cardiology CHU Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Delaubier","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation CHU Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Gilbert\u2010Dussardier","sequence":"additional","affiliation":[{"name":"Department of Genetics CHU Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Christiaens","sequence":"additional","affiliation":[{"name":"Department of Cardiology CHU Poitiers Poitiers France"},{"name":"Univ Poitiers  Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigue","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Cardiology CHU Poitiers Poitiers France"},{"name":"Univ Poitiers  Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.07.032"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.1.164"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euq423"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2003.11.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0066-782X2012005000021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13426"},{"key":"e_1_2_8_8_1","first-page":"32086","article-title":"Left ventricular longitudinal strain impairment predicts cardiovascular events in asymptomatic type 1 myotonic dystrophy","volume":"19","author":"Garcia R.","year":"2017","journal-title":"International Journal of 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