{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:30:59Z","timestamp":1769106659995,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T00:00:00Z","timestamp":1538092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Baseline predictors of myocardial recovery after cardiac resynchronization therapy (CRT) in left bundle branch block (LBBB)\u2010associated idiopathic nonischemic cardiomyopathy (NICM) are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study included subjects with idiopathic NICM, left ventricular ejection fraction (LVEF) \u226435%, and LBBB. Myocardial recovery was defined as post\u2010CRT LVEF \u226550%. Logistic regression analyses described associations between baseline characteristics and myocardial recovery. Cox regression analyses estimated the hazard ratio (HR) between myocardial recovery status and adverse clinical events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 105 subjects (mean age 61\u00a0years, 44% male, mean initial LVEF 22.6%\u00a0\u00b1\u00a06.6%, 81% New York Heart Association class III, and 98% CRT\u2010defibrillators), myocardial recovery after CRT was observed in 56 (54%) subjects. Hypertension, heart rate, and serum blood urea nitrogen (BUN) had negative associations with myocardial recovery in univariable analyses. These associations persisted in multivariable analysis: hypertension (odds ratio (OR), 0.40; 95% confidence interval (CI), 0.17\u20130.95; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04), heart rate (OR per 10\u00a0bpm, 0.69; 95% CI, 0.48\u20130.997; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.048), and serum BUN (OR per 1\u00a0mg\/dl, 0.94; 95% CI, 0.88\u20130.99; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). Subjects with post\u2010CRT LVEF \u226550%, when compared to &lt;50%, had lower risk for adverse clinical events (heart failure hospitalization, appropriate implantable cardioverter\u2010defibrillator shock, appropriate anti\u2010tachycardia pacing therapy, ventricular assist device implantation, heart transplantation, and death) over a median follow\u2010up of 75.9\u00a0months (HR, 0.38; 95% CI, 0.16\u20130.88; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In LBBB\u2010associated idiopathic NICM, myocardial recovery after CRT was associated with absence of hypertension, lower heart rate, and lower serum BUN. Those with myocardial recovery had fewer adverse clinical events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12603","type":"journal-article","created":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T05:35:06Z","timestamp":1538199306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Myocardial recovery after cardiac resynchronization therapy in left bundle branch block\u2010associated idiopathic nonischemic cardiomyopathy: A NEOLITH II substudy"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8388-2146","authenticated-orcid":false,"given":"Norman C.","family":"Wang","sequence":"first","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliza","family":"Hussain","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan C.","family":"Adelstein","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Althouse","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Sharbaugh","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep K.","family":"Jain","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa A.","family":"Shalaby","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew H.","family":"Voigt","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Saba","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw323"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.04.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.03.009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006855"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002208"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.10.125"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.06.081"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2007.02.005"},{"issue":"2","key":"e_1_2_7_10_1","first-page":"109","article-title":"Heart rate of beta\u2010blocker dose? 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