{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:26:42Z","timestamp":1762918002635,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sex differences in clinical outcomes for left bundle branch block (LBBB)\u2010associated idiopathic nonischemic cardiomyopathy (NICM) after cardiac resynchronization therapy (CRT) are not well described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study at an academic medical center included subjects with LBBB\u2010associated idiopathic NICM who received CRT. Cox regression analyses estimated the hazard ratios (HRs) between sex and clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 123 total subjects (mean age 62\u00a0years, mean initial left ventricular ejection fraction 22.8%, 76% New York Heart Association class III, and 98% CRT\u2010defibrillators), 55 (45%) were men and 68 (55%) were women. The median follow\u2010up time after CRT was 72.4\u00a0months. Similar risk for adverse clinical events (heart failure hospitalization, appropriate implantable cardioverter\u2010defibrillator shock, appropriate antitachycardia pacing therapy, ventricular assist device implantation, heart transplantation, and death) was observed between men and women (HR, 1.20; 95% confidence interval [CI] 0.57\u20132.51; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.63). This persisted in multivariable analyses. Men and women had similar risk for all\u2010cause mortality in univariable analysis, but men had higher risk in the final multivariable model that adjusted for age at diagnosis, QRS duration, and left ventricular end\u2010diastolic dimension index (HR, 4.55; 95% CI, 1.26\u201316.39; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02). The estimated 5\u2010year mortality was 9.5% for men and 6.9% for women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In LBBB\u2010associated idiopathic NICM, men have higher risk for all\u2010cause mortality after CRT when compared to women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12641","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T06:34:26Z","timestamp":1553754866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex\u2010specific clinical outcomes after cardiac resynchronization therapy in left bundle branch block\u2010associated idiopathic nonischemic cardiomyopathy: A NEOLITH II substudy"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8388-2146","authenticated-orcid":false,"given":"Norman C.","family":"Wang","sequence":"first","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ure","family":"Mezu\u2010Chukwu","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan C.","family":"Adelstein","sequence":"additional","affiliation":[{"name":"Albany Medical Center Albany New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Althouse","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Sharbaugh","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep K.","family":"Jain","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa A.","family":"Shalaby","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew H.","family":"Voigt","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Saba","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/chf.12028"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.061"},{"issue":"6","key":"e_1_2_7_4_1","first-page":"258","article-title":"Asymptomatic left bundle branch block predicts new\u2010onset congestive heart failure and death from cardiovascular disease","volume":"3","author":"Azadani P. N.","year":"2012","journal-title":"Cardiology Research"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.10.055"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412083312307"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000217141.20163.23"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22917"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)00160-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2003.159"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026056"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.01.065"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2018-313415"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.590"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.678375"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.05.054"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198710223171717"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.065"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.592"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.11.010"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.013"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.6848"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.10.053"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.02.021"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.04.001"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.060"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12603"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13264"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.22.2656"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.12.020"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/00031305.2016.1154108"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-008-9287-1"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.07.002"},{"issue":"16","key":"e_1_2_7_35_1","first-page":"e240","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: A report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"128","author":"Yancy C. W.","year":"2013","journal-title":"Circulation"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.000217"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.114.001548"}],"container-title":["Annals of Noninvasive Electrocardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanec.12641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.12641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anec.12641","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.12641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T07:59:06Z","timestamp":1694332746000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/anec.12641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,27]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/anec.12641"],"URL":"https:\/\/doi.org\/10.1111\/anec.12641","archive":["Portico"],"relation":{},"ISSN":["1082-720X","1542-474X"],"issn-type":[{"type":"print","value":"1082-720X"},{"type":"electronic","value":"1542-474X"}],"subject":[],"published":{"date-parts":[[2019,3,27]]},"assertion":[{"value":"2018-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12641"}}