{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:22:07Z","timestamp":1787235727540,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007460","name":"Arvid Nilssons Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007460","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Abnormal P\u2010wave morphology (\n PWM<\/jats:styled-content>\n ) has been associated with a history of atrial fibrillation (\n AF<\/jats:styled-content>\n ) in earlier studies. Although lone\n AF<\/jats:styled-content>\n is believed to have substantial genetic basis, studies on associations between single nucleotide polymorphisms (\n SNP<\/jats:styled-content>\n ) linked to lone\n AF<\/jats:styled-content>\n and\n PWM<\/jats:styled-content>\n have not been reported. We aimed to assess whether\n SNP<\/jats:styled-content>\n s previously associated with lone\n AF<\/jats:styled-content>\n (rs2200733, rs13376333, rs3807989, and rs11047543) are also linked to P\u2010wave abnormalities.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Four\n SNP<\/jats:styled-content>\n s were studied in 176 unrelated individuals with early\u2010onset lone\n AF<\/jats:styled-content>\n (age at onset <50\u00a0years), median age 38\u00a0years (19\u201363\u00a0years), 149 men. Using sinus rhythm\n ECG<\/jats:styled-content>\n , orthogonal\n PWM<\/jats:styled-content>\n was classified as Type 1\u2014positive in leads X and Y and negative in lead Z, Type 2\u2014positive in leads X and Y and biphasic (\u2212\/+) in lead Z, Type 3\u2014positive in lead X and biphasic in lead Y (+\/\u2212), and the remaining as atypical.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Two\n SNP<\/jats:styled-content>\n s were found to be significantly associated with altered P\u2010wave morphology distribution: rs3807989 near the gene\n \n CAV<\/jats:styled-content>\n 1\/\n CAV<\/jats:styled-content>\n 2\n <\/jats:italic>\n and rs11047543 near the gene\n \n SOX<\/jats:styled-content>\n 5\n <\/jats:italic>\n . Both\n SNP<\/jats:styled-content>\n s were associated with a higher risk of non\u2010Type 1 P\u2010wave morphology (rs3807989:\n OR<\/jats:styled-content>\n \u00a0=\u00a04.8, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a02.3\u201310.2,\n p<\/jats:italic>\n \u00a0<\u00a00.001; rs11047543:\n OR<\/jats:styled-content>\n \u00a0=\u00a04.7, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.1\u201320.5,\n p<\/jats:italic>\n \u00a0=\u00a00.04). No association was observed for rs2200733 and rs13376333.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In this study, the two variants rs3807989 and rs11047543, previously associated with\n PR<\/jats:styled-content>\n interval and lone\n AF<\/jats:styled-content>\n , were associated with altered P\u2010wave morphology distribution in patients with early\u2010onset lone\n AF<\/jats:styled-content>\n . These findings suggest that common genetic variants may modify atrial conduction properties.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/anec.12661","type":"journal-article","created":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T03:24:10Z","timestamp":1559359450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic variants on chromosomes 7p31 and 12p12 are associated with abnormal atrial electrical activation in patients with early\u2010onset lone atrial fibrillation"],"prefix":"10.1111","volume":"24","author":[{"given":"Mariam B.","family":"Seifert","sequence":"first","affiliation":[{"name":"The Center for Integrative Electrocardiology Arrhythmia Clinic Sk\u00e5ne University Hospital Lund University (CIEL) Lund Sweden"},{"name":"Department of Cardiology Frederiksberg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten S.","family":"Olesen","sequence":"additional","affiliation":[{"name":"Danish National Research Foundation Center for Cardiac Arrhythmia Copenhagen Denmark"},{"name":"Department of Biomedical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid E.","family":"Christophersen","sequence":"additional","affiliation":[{"name":"The Department of Medical Genetics Oslo University Hospital Oslo Norway"},{"name":"Department of Medical Research B\u00e6rum Hospital Vestre Viken Hospital Trust Rud Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas B.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Danish National Research Foundation Center for Cardiac Arrhythmia Copenhagen Denmark"},{"name":"Department of Biomedical Sciences University of Copenhagen Copenhagen 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