{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:01:17Z","timestamp":1778644877969,"version":"3.51.4"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T00:00:00Z","timestamp":1564358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brugada syndrome (BrS) is a common cause of sudden cardiac death (SCD). There is recent evidence that atrial fibrillation (AF) is associated with increased risk of SCD in general population. However, whether AF increases a risk of major arrhythmic events (MAE) in patients with BrS is still unclear. We performed a systematic review and meta\u2010analysis to explore the effect of AF on MAE in BrS population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the databases of MEDLINE and EMBASE from inception to March 2019. Included studies were published cohort studies reporting rates of MAE (ventricular fibrillation, sustained ventricular tachycardia, SCD, or sudden cardiac arrest) in BrS patients, with and without previous documented AF. Data from each study were combined using the random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six studies from 1,703 patients were included. There was a significant association between AF and an increased risk of MAE in patients with BrS (pooled OR\u00a0=\u00a02.37, 95% CI\u00a0=\u00a01.36\u20134.13, <jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a0.002, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a040.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our meta\u2010analysis demonstrated that AF is associated with an increased risk of MAE in patients with BrS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12676","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T08:39:47Z","timestamp":1564389587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Atrial fibrillation and risk of major arrhythmic events in Brugada syndrome: A meta\u2010analysis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0959-5576","authenticated-orcid":false,"given":"Jakrin","family":"Kewcharoen","sequence":"first","affiliation":[{"name":"University of Hawaii Internal Medicine Residency Program Honolulu HI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9419-5854","authenticated-orcid":false,"given":"Pattara","family":"Rattanawong","sequence":"additional","affiliation":[{"name":"University of Hawaii Internal Medicine Residency Program Honolulu HI USA"},{"name":"Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanavuth","family":"Kanitsoraphan","sequence":"additional","affiliation":[{"name":"University of Hawaii Internal Medicine Residency Program Honolulu HI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raktham","family":"Mekritthikrai","sequence":"additional","affiliation":[{"name":"University of Hawaii Internal Medicine Residency Program Honolulu HI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7956-0574","authenticated-orcid":false,"given":"Narut","family":"Prasitlumkum","sequence":"additional","affiliation":[{"name":"University of Hawaii Internal Medicine Residency Program Honolulu HI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prapaipan","family":"Putthapiban","sequence":"additional","affiliation":[{"name":"Department of Medicine Einstein Medical Center Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poemlarp","family":"Mekraksakit","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Texas Tech University Health Sciences Center Lubbock TX 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