{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:37:20Z","timestamp":1791308240109,"version":"4.3.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prolonged QTc interval observed in daily practice is often deemed to be drug induced and might result in drug discontinuation, with possible therapeutic consequences. However, whether clinically significant prolonged QTc may be due to within\u2010individual variability occurs has yet to be described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study documenting within\u2010individual QTc variability in subjects attending annual routine medical evaluation. At each visit, QT interval was measured and corrected for heart rate using Bazett and three other commonly used formulae. Outcome measures were rates of \u0394QTc \u226560 msec, absolute QTc \u2265500 msec and QTc \u226525% from baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 188 subjects [54 (29%)] females were recruited. Mean age at first ECG was 54\u00a0\u00b1\u00a012.8\u00a0years with mean time interval of 12.2\u00a0\u00b1\u00a01.1\u00a0months between measurements. Mean Bazett QTc was higher compared to the other 3 formulae: 412\u00a0\u00b1\u00a020 vs. 400\u00a0\u00b1\u00a016 msec. Using Bazett formula, 18\/188 (9.6%) and 5\/188 (2.7%) subjects showed at least one measurement with \u0394QTc \u226560\u00a0msec and QTc \u2265500\u00a0msec, respectively. Of the former, 5\/18 (27.8%) showed QTc \u226525% prolongation. In multivariate analysis, QTc \u2265500\u00a0msec was significantly associated with number of measurements (HR: 5.01, 95%CI: 1.21\u201320.78,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.026) with no effect of other known confounders. Lower rates were demonstrated with the other three formulae.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In clinical practice, significant prolonged QTc may be attributed to within\u2010individual variability, particularly when adjusting the QT interval with Bazett correction. This should be taken into consideration when decisions on changing current drug regimens are to be made.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anec.12699","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T10:46:13Z","timestamp":1568025973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinically significant incidental QTc prolongation is subject to within\u2010individual variability"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6631-8415","authenticated-orcid":false,"given":"Itai","family":"Gueta","sequence":"first","affiliation":[{"name":"The Institute of Clinical Pharmacology and Toxicology Sheba Medical Center Tel Hashomer Israel"},{"name":"Sackler School of Medicine Tel Aviv University Tel Aviv 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