{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:31:54Z","timestamp":1762867914708,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The total QT interval comprises both ventricular depolarization and repolarization currents. Understanding how HIV serostatus and other risk factors influence specific QT interval subcomponents could improve our mechanistic understanding of arrhythmias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve\u2010lead electrocardiograms (ECGs) were acquired in 774 HIV\u2010infected (HIV+) and 652 HIV\u2010uninfected (HIV\u2212) men from the Multicenter AIDS Cohort Study. Individual QT subcomponent intervals were analyzed: R\u2010onset to R\u2010peak, R\u2010peak to R\u2010end, JT segment, T\u2010onset to T\u2010peak, and T\u2010peak to T\u2010end. Using multivariable linear regressions, we investigated associations between HIV serostatus and covariates, including serum concentrations of inflammatory biomarkers such as interleukin\u20106 (IL\u20106), and each QT subcomponent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjustment for demographics and risk factors, HIV+ versus HIV\u2212 men differed only in repolarization phase durations with longer T\u2010onset to T\u2010peak by 2.3\u00a0ms (95% CI 0\u20134.5, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) and T\u2010peak to T\u2010end by 1.6\u00a0ms (95% CI 0.3\u20132.9, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Adjusting for inflammation attenuated the strength and significance of the relationship between HIV serostatus and repolarization. The highest tertile of IL\u20106 was associated with a 7.3\u00a0ms (95% CI 3.2\u201311.5, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) longer T\u2010onset to T\u2010peak. Age, race, body mass index, alcohol use, and left ventricular hypertrophy were each associated with up to 2.2\u201312.5\u00a0ms longer T\u2010wave subcomponents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HIV seropositivity, in combination with additional risk factors including increased systemic inflammation, is associated with longer T\u2010wave subcomponents. These findings could suggest mechanisms by which the ventricular repolarization phase is lengthened and thereby contribute to increased arrhythmic risk in men living with HIV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12705","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T05:23:05Z","timestamp":1568956985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Associations between QT interval subcomponents, HIV serostatus, and inflammation"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4958-5145","authenticated-orcid":false,"given":"Katherine C.","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Bhondoekhan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina A.","family":"Haberlen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ashikaga","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd T.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Department of Medicine Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Budoff","sequence":"additional","affiliation":[{"name":"Los Angeles Biomedical Research Institute at Harbor\u2010UCLA Medical Center Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gypsyamber","family":"D'Souza","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared W.","family":"Magnani","sequence":"additional","affiliation":[{"name":"School of Medicine University of Pittsburgh Medical Center University of Pittsburgh, and the Heart and Vascular Institute Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence A.","family":"Kingsley","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases and Microbiology and Epidemiology University of Pittsburgh Graduate School of Public Health Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J.","family":"Palella","sequence":"additional","affiliation":[{"name":"Department of Medicine Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph B.","family":"Margolick","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otoniel","family":"Mart\u00ednez\u2010Maza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Microbiology, Immunology &amp; Molecular Genetics David Geffen School of Medicine at UCLA UCLA Fielding School of Public Health Los Angeles California"},{"name":"Department of Epidemiology UCLA Fielding School of Public Health Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean F.","family":"Altekruse","sequence":"additional","affiliation":[{"name":"Epidemiology Branch, Prevention and Population Sciences Program Division of Cardiovascular Sciences National Heart, Lung, and Blood Institute Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsayed Z.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Cardiology Section Department of Epidemiology and Prevention and Department of Medicine Epidemiological Cardiology Research Center (EPICARE) Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy S.","family":"Post","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins University School of Medicine Baltimore Maryland"},{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00355.2007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208321"},{"issue":"3","key":"e_1_2_8_4_1","first-page":"346","article-title":"Addictive drugs, arrhythmias, and cardiac inward rectifiers","volume":"19","author":"Bebarova M.","year":"2017","journal-title":"Europace"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.02.017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2014.03.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005774"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.06.025"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.022"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000725"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.180065"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22455"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010595"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-311079"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0098-z"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.07.033"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.07.023"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.9.943"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur426"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00002.2005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-015-0838-z"},{"issue":"10","key":"e_1_2_8_22_1","article-title":"Association between QT\u2010interval components and sudden cardiac death: The ARIC study (Atherosclerosis Risk in Communities)","volume":"10","author":"O'Neal W. T.","year":"2017","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2018.04.004"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.960658"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003607"},{"issue":"9","key":"e_1_2_8_26_1","first-page":"740","article-title":"Detailed analysis of the impact of age on the QT interval","volume":"13","author":"Rabkin S. W.","year":"2016","journal-title":"Journal of Geriatric Cardiology"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.015673"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.02.005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.04.035"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4950250706"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.215871"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.534735"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.067"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.024"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr170"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000545"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.05.024"},{"volume-title":"QTdrugs list","author":"Woosley R. L.","key":"e_1_2_8_38_1"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2018-313667"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20030010"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00713-7"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.5.H1968"}],"container-title":["Annals of Noninvasive Electrocardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanec.12705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.12705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anec.12705","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.12705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T07:01:59Z","timestamp":1694070119000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/anec.12705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,19]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/anec.12705"],"URL":"https:\/\/doi.org\/10.1111\/anec.12705","archive":["Portico"],"relation":{},"ISSN":["1082-720X","1542-474X"],"issn-type":[{"type":"print","value":"1082-720X"},{"type":"electronic","value":"1542-474X"}],"subject":[],"published":{"date-parts":[[2019,9,19]]},"assertion":[{"value":"2019-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12705"}}