{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:58:12Z","timestamp":1760029092628,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","award":["n.a."],"award-info":[{"award-number":["n.a."]}],"id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Implantation of the subcutaneous implantable cardioverter\u2010defibrillator (S\u2010ICD) is spreading and has been shown to be safe and effective; however, it does not provide brady\u2010pacing. Currently, data on the need for brady\u2010pacing and cardiac resynchronization therapy (CRT) implantation in patients with ICD indication are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Multicenter Automatic Defibrillator Implantation Trial (MADIT)\u2010II enrolled post\u2010MI patients with reduced ejection fraction (EF\u00a0\u2264\u00a035%), randomized to either an implantable cardioverter\u2010defibrillator (ICD) or conventional medical therapy. Kaplan\u2013Meier analyses and multivariate Cox models were performed to assess the incidence and predictors of pacemaker (PM), or CRT implantation in the conventional arm of MADIT\u2010II, after excluding 32 patients (6.5%) with a previously implanted PM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the median follow\u2010up of 20\u00a0months, 24 of 458 patients (5.2%) were implanted with a PM or a CRT (19 PM, 5 CRT). Symptomatic sinus bradycardia was the primary indication for PM implantation (<jats:italic>n<\/jats:italic>\u00a0=\u00a09, 37%), followed by AV block (<jats:italic>n<\/jats:italic>\u00a0=\u00a05, 21%), tachy\u2010brady syndrome (<jats:italic>n<\/jats:italic>\u00a0=\u00a04, 17%), and carotid sinus hypersensitivity (<jats:italic>n<\/jats:italic>\u00a0=\u00a01, 4%). Baseline PR interval &gt;200\u00a0ms (HR\u00a0=\u00a03.07, 95% CI: 1.24\u20137.57, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02), and CABG before enrollment (HR\u00a0=\u00a06.88, 95% CI: 1.58\u201329.84, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01) predicted subsequent PM\/CRT implantation. Patients with PM\/CRT implantation had a significantly higher risk for heart failure (HR\u00a0=\u00a02.67, 95% CI\u00a0=\u00a01.38\u20135.14, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003), but no increased mortality risk (HR\u00a0=\u00a01.06, 95% CI\u00a0=\u00a00.46\u20132.46, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.89).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The short\u2010term need for ventricular pacing or CRT implantation in patients with MADIT\u2010II ICD indication was low, especially in those with a normal baseline PR interval, and such patients are appropriate candidates for the subcutaneous ICD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12744","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T11:21:08Z","timestamp":1580296868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Need for pacing in patients who qualify for an implantable cardioverter\u2010defibrillator: Clinical implications for the subcutaneous ICD"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-289X","authenticated-orcid":false,"given":"Valentina","family":"Kutyifa","sequence":"first","affiliation":[{"name":"Heart Research Follow\u2010Up Program University of Rochester Medical Center Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer Z.","family":"Rosero","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010Up Program University of Rochester Medical Center Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"McNitt","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010Up Program University of Rochester Medical Center Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bronislava","family":"Polonsky","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010Up Program University of Rochester Medical Center Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary W.","family":"Brown","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010Up Program University of Rochester Medical Center Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Zareba","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010Up Program University of Rochester Medical Center Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010Up Program University of Rochester Medical Center Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-006-9065-x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy083"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.044"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.02.047"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.036"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318276ce9b"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.4598"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.05.016"},{"issue":"1","key":"e_1_2_9_12_1","first-page":"A19187","article-title":"Predictors of right ventricular pacing in ICD recipients without baseline pacing needs","volume":"136","author":"Kalantarian S. 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