{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:50:10Z","timestamp":1765079410991,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sudden infant death syndrome is more frequent in preterm infants (PTI) than term infants and may be due to cardiac repolarization instability, which may manifest as T\u2010wave alternans (TWA) on the electrocardiogram (ECG). Therefore, the aim of the present work was to analyze TWA in nonpathological PTI and to open an issue on its physiological interpretation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical population consisted of ten nonpathological PTI (gestational age ranging from 29<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/anec12745-math-0001.png\" xlink:title=\"urn:x-wiley:1082720X:media:anec12745:anec12745-math-0001\"\/> to 34<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/anec12745-math-0002.png\" xlink:title=\"urn:x-wiley:1082720X:media:anec12745:anec12745-math-0002\"\/>\u00a0weeks; birth weight ranging from 0.84 to 2.10\u00a0kg) from whom ECG recordings were obtained (\u201cPreterm infant cardio\u2010respiratory signals database\u201d by Physionet). TWA was identified through the heart\u2010rate adapting match filter method and characterized in terms of mean amplitude values (TWAA). TWA correlation with several other clinical and ECG features, among which gestational age\u2013birth weight ratio, RR interval, heart\u2010rate variability, and QT interval, was also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TWA was variable among infants (TWAA\u00a0=\u00a026\u00a0\u00b1\u00a011\u00a0\u00b5V). Significant correlations were found between TWAA versus birth weight (<jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a0\u22120.72, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02), TWAA versus gestational age\u2013birth weight ratio (<jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a00.76, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02) and TWAA versus heart\u2010rate variability (<jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a0\u22120.71, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our preliminary retrospective study suggests that nonpathological PTI show TWA of few tens of \u00b5V, the interpretation of which is still an open issue but could indicate a condition of cardiac risk possibly related to the low development status of the infant. Further investigations are needed to solve this issue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12745","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T17:09:27Z","timestamp":1580144967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["T\u2010Wave Alternans in Nonpathological Preterm Infants"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-3530","authenticated-orcid":false,"given":"Ilaria","family":"Marcantoni","sequence":"first","affiliation":[{"name":"Department of Information Engineering Universit\u00e0 Politecnica delle Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-7216","authenticated-orcid":false,"given":"Agnese","family":"Sbrollini","sequence":"additional","affiliation":[{"name":"Department of Information Engineering Universit\u00e0 Politecnica delle Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Agostinelli","sequence":"additional","affiliation":[{"name":"Department of Information Engineering Universit\u00e0 Politecnica delle Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca Chiara","family":"Surace","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Congenital Cardiac Surgery and Cardiology Ospedali Riuniti Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Colaneri","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Congenital Cardiac Surgery and Cardiology Ospedali Riuniti Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-8379","authenticated-orcid":false,"given":"Micaela","family":"Morettini","sequence":"additional","affiliation":[{"name":"Department of Information Engineering Universit\u00e0 Politecnica delle Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Congenital Cardiac Surgery and Cardiology Ospedali Riuniti Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9474-7046","authenticated-orcid":false,"given":"Laura","family":"Burattini","sequence":"additional","affiliation":[{"name":"Department of Information Engineering Universit\u00e0 Politecnica delle Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,27]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"353","article-title":"An analysis of the time relations of electrocardiograms","volume":"7","author":"Bazett H. 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