{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:52:47Z","timestamp":1762642367081,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V103C\u2010042","V103C\u2010126","V103E7\u2010002","V104C\u2010131","V104E7\u2010003","V105C\u201060","V106C\u2010114","V107C\u2010099","VGHUS107\u2010G1\u20108\u20101","VGHUST103\u2010G1\u20103\u20101"],"award-info":[{"award-number":["V103C\u2010042","V103C\u2010126","V103E7\u2010002","V104C\u2010131","V104E7\u2010003","V105C\u201060","V106C\u2010114","V107C\u2010099","VGHUS107\u2010G1\u20108\u20101","VGHUST103\u2010G1\u20103\u20101"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST\u2010102\u20102314\u2010B\u2010010\u2010033\u2010MY3","MOST\u2010105\u20102314\u2010B\u2010010\u2010003\u2010MY3"],"award-info":[{"award-number":["MOST\u2010102\u20102314\u2010B\u2010010\u2010033\u2010MY3","MOST\u2010105\u20102314\u2010B\u2010010\u2010003\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The autonomic activity plays a critical role in generating paroxysmal atrial fibrillation (PAF). This study aimed to evaluate the changes in the autonomic nerve activity before and after PAF events in patients with and without ischemic heart disease (IHD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 49 patients (71.43\u00a0\u00b1\u00a012.24\u00a0years old, 26 males) with PAF events lasting more than 30\u00a0s during 24\u2010hr ambulatory Holter monitoring. The 20\u2010min intervals before and after PAF events were divided into eight segments of 5\u00a0min each. Heart rate variability (HRV) analyses of the time and frequency domains were applied to each time segment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with IHD had significant increases in the root mean square successive differences (r\u2010MSSD, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008) and HF component (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.04), followed by a significant increase in the LF\/HF ratio (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02) preceding the onset of PAF. Patients without IHD had only a significant increase in the r\u2010MSSD (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.045) preceding the onset of PAF. During the termination of PAF events, patients in both the IHD and control groups had a significantly decreased r\u2010MSSD and HF, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ischemic heart disease causes a sympathovagal imbalance in the initiation of PAF. Decreased parasympathetic activity regulated the termination of PAF in both the IHD and control groups. The modification of the autonomic nervous system (ANS) activity should be individualized due to the autonomic complexity in AF arrhythmogenesis and termination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12767","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T08:43:12Z","timestamp":1590482592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Autonomic modulation before and after paroxysmal atrial fibrillation events in patients with ischemic heart disease"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2345-0154","authenticated-orcid":false,"given":"Ting\u2010Wei","family":"Ernie Liao","sequence":"first","affiliation":[{"name":"Faculty of Medicine School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Institute of Clinical Medicine Cardiovascular Research Institute National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9102-227X","authenticated-orcid":false,"given":"Li\u2010Wei","family":"Lo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Institute of Clinical Medicine Cardiovascular Research Institute National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yenn\u2010Jiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Institute of Clinical Medicine Cardiovascular Research Institute National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7030-8471","authenticated-orcid":false,"given":"Shih\u2010Lin","family":"Chang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Institute of Clinical Medicine Cardiovascular Research Institute National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5715-2070","authenticated-orcid":false,"given":"Yu\u2010Feng","family":"Hu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Institute of Clinical Medicine Cardiovascular Research Institute National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5879-4136","authenticated-orcid":false,"given":"Cheng\u2010I","family":"Wu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Institute of Clinical Medicine Cardiovascular Research Institute National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8960-1301","authenticated-orcid":false,"given":"Fa\u2010Po","family":"Chung","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Institute of Clinical Medicine Cardiovascular Research Institute National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze\u2010Fan","family":"Chao","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Institute of Clinical Medicine Cardiovascular Research Institute National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u2010Nan","family":"Liao","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Institute of Clinical Medicine Cardiovascular Research Institute National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Ann","family":"Chen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Institute of Clinical Medicine Cardiovascular Research Institute National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1885-5857(08)60091-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.112.972273"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000053957.15389.9b"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303772"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(98)00305-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2007.890741"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.919829"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(98)00231-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13150"},{"key":"e_1_2_10_11_1","first-page":"A53","article-title":"Classical risk factors and emerging elements in the risk profile for coronary artery disease","volume":"19","author":"Gensini G. F.","year":"1998","journal-title":"European Heart Journal"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(98)00494-9"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13045"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-5273(98)00241-1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz425"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2016.0968"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.05.016"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014868"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2017.06.005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61682-2"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(02)02837-0"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2005.11.010"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4482"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.070"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1991.260.3.H985"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2017.00258"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.139"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014145"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.309732"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2003.02462.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.100.20.2079"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euj043"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000281"}],"container-title":["Annals of Noninvasive Electrocardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanec.12767","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.12767","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anec.12767","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.12767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T11:31:58Z","timestamp":1692444718000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/anec.12767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,26]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/anec.12767"],"URL":"https:\/\/doi.org\/10.1111\/anec.12767","archive":["Portico"],"relation":{},"ISSN":["1082-720X","1542-474X"],"issn-type":[{"type":"print","value":"1082-720X"},{"type":"electronic","value":"1542-474X"}],"subject":[],"published":{"date-parts":[[2020,5,26]]},"assertion":[{"value":"2020-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12767"}}