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The association between wide QRS\u2010T angles and inflammatory activation is however not fully understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>1,094 study participants of both sexes, 50\u201364\u00a0years old, were included from a randomly selected population\u2010based cohort as a part of the Swedish CArdioPulmonary bioImage Study (SCAPIS) pilot study. Serum samples were analyzed for markers of inflammation, cardiac wall stress\/injury, and the metabolic syndrome. Wide QRS\u2010T angles were defined using Frank vectorcardiography. Variables were analyzed through unsupervised principal component analysis (PCA) as well as Orthogonal Projections to Latent Structures (OPLS) modeling. In addition, a subset of study participants was analyzed in a post hoc matched group design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Wide QRS\u2010T angles correlated positively with markers of inflammation, cardiac wall stress\/injury, the metabolic syndrome, and male sex in both PCA and OPLS models. In the matched post hoc analysis, participants with wide QRS\u2010T angles had significantly higher counts of white blood cells (WBC) and neutrophils in comparison with matched controls. WBC as well as the number of neutrophils, monocytes, basophils, eosinophils and levels of C\u2010reactive protein, IL\u20101, IL\u20104, IL\u20106, TNF\u2010\u03b1, and NT\u2010pro\u2010BNP were also significantly higher in comparison with healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Markers of inflammatory activation and cardiac injury\/wall stress were significantly higher in the presence of wide QRS\u2010T angles. These results corroborate an association between abnormal electrophysiological function and inflammatory activation and may have implications for the prediction of SCD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12781","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T07:29:19Z","timestamp":1594193359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Wide QRS\u2010T angles are associated with markers of increased inflammatory activity independently of hypertension and diabetes"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3124-6359","authenticated-orcid":false,"given":"Mikael","family":"Sandstedt","sequence":"first","affiliation":[{"name":"Region V\u00e4stra G\u00f6taland Department of Clinical Chemistry Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Laboratory Medicine Institute of Biomedicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Bergfeldt","sequence":"additional","affiliation":[{"name":"Region V\u00e4stra G\u00f6taland Department of Cardiology Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joakim","family":"Sandstedt","sequence":"additional","affiliation":[{"name":"Region V\u00e4stra G\u00f6taland Department of Clinical Chemistry Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Laboratory Medicine Institute of Biomedicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Lundqvist","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuel","family":"Fryk","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per\u2010Anders","family":"Jansson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Region V\u00e4stra G\u00f6taland Gothia Forum Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillemor","family":"Mattsson Hult\u00e9n","sequence":"additional","affiliation":[{"name":"Region V\u00e4stra G\u00f6taland Department of Clinical Chemistry Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.18869\/acadpub.ibj.21.2.77"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000017493.03108.1C"},{"key":"e_1_2_9_4_1","first-page":"e272","article-title":"2017 AHA\/ACC\/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","volume":"138","author":"Al\u2010Khatib S. 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