{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:21:23Z","timestamp":1778916083687,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["NIH 1L30HL134084\u201001"],"award-info":[{"award-number":["NIH 1L30HL134084\u201001"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Risk stratification in non\u2010ischemic myocardial disease poses a challenge. While cardiovascular magnetic resonance (CMR) is a comprehensive tool, the electrocardiogram (ECG) provides quick impactful clinical information. Studying the relationships between CMR and ECG can provide much\u2010needed risk stratification. We evaluated the electrocardiographic signature of myocardial fibrosis defined as presence of late gadolinium enhancement (LGE) or extracellular volume fraction (ECV) \u226529%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated 240 consecutive patients (51% female, 47.1\u00a0\u00b1\u00a016.6\u00a0years) referred for a clinical CMR who underwent 12\u2010lead ECGs within 90\u00a0days. ECG parameters studied to determine association with myocardial fibrosis included heart rate, QRS amplitude\/duration, T\u2010wave amplitude, corrected QT and QT peak, and Tpeak\u2010Tend. Abnormal T\u2010wave was defined as low T\u2010wave amplitude \u2264200\u00a0\u00b5V or a negative T wave, both in leads II and V5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 147 (61.3%) patients with myocardial fibrosis, 67 (28.2%) had ECV\u00a0\u2265\u00a029%, and 132 (54.6%) had non\u2010ischemic LGE. An abnormal T\u2010wave was more prevalent in patients with versus without myocardial fibrosis (66% versus 42%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Multivariable analysis demonstrated that abnormal T\u2010wave (OR 1.95, 95% CI 1.09\u20133.49, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03) was associated with myocardial fibrosis (ECV\u00a0\u2265\u00a029% or LGE) after adjustment for clinical covariates (age, gender, history of hypertension, and heart failure). Dynamic nomogram for predicting myocardial fibrosis using clinical parameters and the T\u2010wave was developed: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/normogram.shinyapps.io\/CMR_Fibrosis\/\">https:\/\/normogram.shinyapps.io\/CMR_Fibrosis\/<\/jats:ext-link>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low T\u2010wave amplitude\u00a0\u2264\u00a0200\u00a0\u00b5V or negative T\u2010waves are independently associated with myocardial fibrosis. Prospective evaluation of T\u2010wave amplitude may identify patients with a high probability of myocardial fibrosis and guide further indication for CMR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12819","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T17:25:00Z","timestamp":1608312300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["T\u2010wave and its association with myocardial fibrosis on cardiovascular magnetic resonance examination"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4891-4106","authenticated-orcid":false,"given":"Karolina M.","family":"Zareba","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine The Ohio State University Wexner Medical Center  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vien T.","family":"Truong","sequence":"additional","affiliation":[{"name":"Division of Cardiology The Christ Hospital Health Network  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Mazur","sequence":"additional","affiliation":[{"name":"Division of Cardiology The Christ Hospital Health Network  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M.","family":"Smart","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine The Ohio State University Wexner Medical Center  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Xia","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010Up Program University of Rochester Medical Center  Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Philippe","family":"Couderc","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010Up Program University of Rochester Medical Center  Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subha V.","family":"Raman","sequence":"additional","affiliation":[{"name":"Division of Cardiology Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0240-2"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.624924"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000659"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-9"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-S1-P213"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.09.017"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960230811"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.72.3.495"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-0736(05)80257-2"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs112"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016160816"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225253"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.904300"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-015-0111-7"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10051"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21119"},{"issue":"1","key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12968-017-0389-8","article-title":"Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)","volume":"19","author":"Messroghli D. 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