{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:07:32Z","timestamp":1788480452864,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Electrocardiographic abnormalities, such as PR interval prolongation, have been anecdotally reported in patients with aortic root abscess (ARA). An electrocardiographic marker may be useful in identifying those patients with aortic valve endocarditis who may progress to ARA. The objective of this study is to evaluate the change in the PR interval in patients with surgically confirmed ARA and compare it to age\u2010 and gender\u2010matched controls with echocardiographically or surgically confirmed aortic valve endocarditis but without aortic root abscess and those hospitalized with diagnoses other than endocarditis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were eligible for enrollment if they were 18\u00a0years or older and were hospitalized for either ARA, aortic valve endocarditis, or for unrelated reasons and had at least one 12\u2010lead electrocardiogram (ECG) prior to or on the day of hospitalization and at least one ECG after hospitalization but prior to any cardiac surgical procedure. Delta PR interval, defined as the difference between the pre\u2010 and post\u2010admission PR interval, was the primary outcome of interest. The patients in the ARA group were age\u2010 and gender\u2010matched to patients with aortic valve endocarditis and to those without endocarditis. Comparisons of demographic variables and study outcomes were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen patients with surgically confirmed ARA were enrolled. These patients were age\u2010 and gender\u2010matched to 19 patients with aortic valve endocarditis and 18 patients with no past history or evidence of endocarditis during hospitalization. No difference was noted in the baseline PR interval between the groups. However, the PR interval following admission in the aortic root abscess group (201\u00a0\u00b1\u00a066\u00a0ms) was significantly longer than the PR interval in both the aortic valve endocarditis (162\u00a0\u00b1\u00a027\u00a0ms) (24%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.009) and no endocarditis (143\u00a0\u00b1\u00a024\u00a0ms) (40%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) groups. The primary outcome measure, delta PR interval, was significantly longer in the ARA group (35\u00a0\u00b1\u00a051\u00a0ms) than no endocarditis (\u22125\u00a0\u00b1\u00a017\u00a0ms) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001) and aortic valve endocarditis groups (0.2\u00a0\u00b1\u00a018) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of our study support the notion that the PR interval is more likely to be prolonged in patients with ARA. Since ARA is associated with a high morbidity and mortality, PR interval prolongation in a patient with aortic valve endocarditis should prompt a thorough evaluation for aortic root involvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12849","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T16:55:52Z","timestamp":1620060952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["PR interval prolongation is significantly associated with aortic root abscess: An age\u2010 and gender\u2010matched study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3410-840X","authenticated-orcid":false,"given":"Utkarsh","family":"Kohli","sequence":"first","affiliation":[{"name":"Department of Pediatrics Comer Children's Hospital and Pritzker School of Medicine of the University of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirlene","family":"Obuobi","sequence":"additional","affiliation":[{"name":"Heart &amp; Vascular Center Pritzker School of Medicine of the University of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karima","family":"Addetia","sequence":"additional","affiliation":[{"name":"Heart &amp; Vascular Center Pritzker School of Medicine of the University of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeyoshi","family":"Ota","sequence":"additional","affiliation":[{"name":"Heart &amp; Vascular Center Pritzker School of Medicine of the University of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemal M.","family":"Nayak","sequence":"additional","affiliation":[{"name":"Heart &amp; Vascular Center Pritzker School of Medicine of the University of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.54.1.140"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-020-01409-x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01747-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2015.03.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a059875"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccl.2019.06.003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.12691\/ajmcr-8-9-15"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.04.003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.059253"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"654","DOI":"10.4103\/sja.SJA_330_18","article-title":"Aortic root abscess and the lost art of the physical exam","volume":"12","author":"Landa A. 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