{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:12:14Z","timestamp":1787785934026,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several P\u2010wave indices are associated with the development of atrial fibrillation (AF). However, previous studies have been limited in their ability to reliably diagnose episodes of AF. Implantable loop recorders allow long\u2010term, continuous, and therefore more reliable detection of AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>The aim of this study is to identify and evaluate ECG parameters for predicting AF by analyzing patients with loop recorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 366 patients (mean age 62\u00a0\u00b1\u00a016\u00a0years, mean LVEF 61\u00a0\u00b1\u00a06%, 175 women) without AF who underwent loop recorder implantation between 2010\u20132020. Patients were followed up on a 3 monthly outpatient interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a follow\u2010up of 627\u00a0\u00b1\u00a0409\u00a0days, 75 patients (20%) reached the primary study end point (first detection of AF). Independent predictors of AF were as follows: age \u226568\u00a0years (hazard risk [HR], 2.66; 95% confidence interval [CI], 1.668\u20134.235; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), P\u2010wave amplitude in II &lt;0.1\u00a0mV (HR, 2.11; 95% CI, 1.298\u20133.441; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003), P\u2010wave terminal force in V<jats:sub>1<\/jats:sub>\u00a0\u2264\u00a0\u22124000\u00a0\u00b5V\u00a0\u00d7\u00a0ms (HR, 5.3; 95% CI, 3.249\u20138.636; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001, and advanced interatrial block (HR, 5.01; 95% CI, 2.638\u20139.528; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Our risk stratification model based on these independent predictors separated patients into 4 groups with high (70%), intermediate high (41%), intermediate low (18%), and low (4%) rates of AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study indicated that P\u2010wave indices are suitable for predicting AF episodes. Furthermore, it is possible to stratify patients into risk groups for AF using simple ECG parameters, which is particularly important for patients with cryptogenic stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12854","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T06:06:11Z","timestamp":1620540371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Impact of P\u2010wave indices in prediction of atrial fibrillation\u2014Insight from loop recorder analysis"],"prefix":"10.1111","volume":"26","author":[{"given":"Fabienne","family":"Kreimer","sequence":"first","affiliation":[{"name":"University Hospital St Josef Hospital, Cardiology and Rhythmology Ruhr University  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assem","family":"Aweimer","sequence":"additional","affiliation":[{"name":"University Hospital Bergmannsheil, Cardiology and Angiology Ruhr University  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Pflaumbaum","sequence":"additional","affiliation":[{"name":"University Hospital St Josef Hospital, Cardiology and Rhythmology Ruhr University  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"M\u00fcgge","sequence":"additional","affiliation":[{"name":"University Hospital St Josef Hospital, Cardiology and Rhythmology Ruhr University  Bochum Germany"},{"name":"University Hospital Bergmannsheil, Cardiology and Angiology Ruhr University  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-0284","authenticated-orcid":false,"given":"Michael","family":"Gotzmann","sequence":"additional","affiliation":[{"name":"University Hospital St Josef Hospital, Cardiology and Rhythmology Ruhr University  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.10.020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4022\/jafib.1724"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.000102"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy231"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.08.049"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.888"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14608"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.04.017"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.03.053"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2019.09.009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2001.tb00101.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa118"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12321"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014553"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017293"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(77)80209-9"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512179"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.10.075"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.10.009"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04963-9"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.04.026"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.04.012"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12751"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313600"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60443-8"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.534735"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.09.044"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000758"}],"container-title":["Annals of Noninvasive Electrocardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.12854","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anec.12854","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.12854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:30:47Z","timestamp":1693355447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/anec.12854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,7]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/anec.12854"],"URL":"https:\/\/doi.org\/10.1111\/anec.12854","archive":["Portico"],"relation":{},"ISSN":["1082-720X","1542-474X"],"issn-type":[{"value":"1082-720X","type":"print"},{"value":"1542-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,7]]},"assertion":[{"value":"2021-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12854"}}