{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:29:02Z","timestamp":1779892142686,"version":"3.53.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000850","name":"National Heart and Lung Institute","doi-asserted-by":"publisher","award":["RO1HL140924"],"award-info":[{"award-number":["RO1HL140924"]}],"id":[{"id":"10.13039\/501100000850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>TdP is a form of polymorphic ventricular tachycardia which develops in the setting of a prolonged QT interval. There are limited data describing risk factors, treatment, and outcomes of this potentially fatal arrhythmia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our goals were as follows: (1) to validate cases presenting with Torsade de Pointes (TdP), (2) to identify modifiable risk factors, and (3) to describe the management strategies used for TdP and its prognosis in a real\u2010world healthcare setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case\u2013control study (with 2:1\u00a0matching on age, sex, and race\/ethnicity) nested within the Genetic Epidemiology Research on Aging (GERA) cohort. Follow\u2010up of the cohort for case ascertainment was between January 01, 2005 and December 31, 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 56 cases of TdP were confirmed (incidence rate\u00a0=\u00a03.6 per 100,000 persons\/years). The average (SD) age of the TdP cases was 74 (13) years, 55 percent were female, and 16 percent were non\u2010white. The independent predictors of TdP were potassium concentration &lt;3.6\u00a0mEq\/L (OR\u00a0=\u00a010.6), prior history of atrial fibrillation\/flutter (OR\u00a0=\u00a06.2), QTc &gt;480\u00a0ms (OR\u00a0=\u00a04.4) and prior history of coronary artery disease (OR\u00a0=\u00a02.6). Exposure to furosemide and amiodarone was significantly greater in cases than in controls. The most common treatment for TdP was IV magnesium (78.6%) and IV potassium repletion (73.2%). The in\u2010hospital and 1\u2010year mortality rates for TdP cases were 10.7% and 25.0% percent, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings may inform quantitative multivariate risk indices for the prediction of TdP and could guide practitioners on which patients may qualify for continuous ECG monitoring and\/or electrolyte replacement therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12888","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T18:53:22Z","timestamp":1632250402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Torsade de pointes: A nested case\u2013control study in an integrated healthcare delivery system"],"prefix":"10.1111","volume":"27","author":[{"given":"Neha","family":"Mantri","sequence":"first","affiliation":[{"name":"Department of Cardiology Kaiser Permanente San Francisco Medical Center San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan G.","family":"Zaroff","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kaiser Permanente San Francisco Medical Center San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Risch","sequence":"additional","affiliation":[{"name":"Institute for Human Genetics University of California, San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Institute for Human Genetics University of California, San Francisco San Francisco CA USA"},{"name":"Department of Epidemiology and Biostatistics University of California, San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinyemi","family":"Oni\u2010Orisan","sequence":"additional","affiliation":[{"name":"Institute for Human Genetics University of California, San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5622-1839","authenticated-orcid":false,"given":"Carlos","family":"Iribarren","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.74.12.1324"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.115.178616"},{"key":"e_1_2_10_4_1","first-page":"353","article-title":"An analysis of the time\u2010relations of electrocardiograms","volume":"7","author":"Bazett H.","year":"1920","journal-title":"Heart"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2003.10.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199411060-00007"},{"issue":"6","key":"e_1_2_10_8_1","first-page":"103","article-title":"Torsades de pointes: Definition and management","volume":"51","author":"Fontaine G.","year":"1982","journal-title":"Modern Concepts of Cardiovascular Disease"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.01.040"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12157"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3479"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/212178"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.12.S1.110"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(83)80226-5"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.01.060"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.82.5.703"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(08)70653-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.115.178905"},{"key":"e_1_2_10_19_1","first-page":"263","article-title":"tachycardie ventriculaire a\u00b4 deux foyers opposes variables","volume":"59","author":"La D. 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