{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T21:56:20Z","timestamp":1771019780752,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:00:00Z","timestamp":1633132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81530011"],"award-info":[{"award-number":["81530011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800302"],"award-info":[{"award-number":["81800302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The adiponectin\u2010to\u2010leptin (A\/L) ratio has been identified as a potential surrogate biomarker for metabolic disorders. However, it remains unknown whether the serum A\/L ratio is associated with heart rate variability in paroxysmal atrial fibrillation (AF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For this retrospective study, we included consecutive patients who underwent 24\u2010h long\u2010range electrocardiogram examination in our center for paroxysmal AF. The results of echocardiography, heart rate variability tests, and blood tests were also retrieved. Multivariate line regression analysis was performed to evaluate identify factors independently associated with heart rate variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 85 included patients with paroxysmal AF, the median A\/L ratio was 1.71. Univariate analysis indicated that patients with a low A\/L ratio (&lt;1.71, <jats:italic>n<\/jats:italic>\u00a0=\u00a042) had a lower high\u2010frequency (HF) power and a higher hs\u2010CRP level, low\u2010frequency (LF) power, and LF\/HF ratio than those with a high A\/L ratio (\u22651.71, <jats:italic>n<\/jats:italic>\u00a0=\u00a043). Multivariate linear regression analysis showed that the serum leptin concentration was independently and positively associated with LF (\u03b2\u00a0=\u00a00.175, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.028), while the serum adiponectin concentration was independently and positively associated with HF (\u03b2\u00a0=\u00a00.321, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.001). Moreover, the A\/L ratio was independently and negatively associated with the LF\/HF ratio (\u03b2\u00a0=\u00a0\u22120.276, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The A\/L ratio was independently and negatively associated with the LF\/HF ratio in patients with new\u2010onset paroxysmal AF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12896","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T12:27:47Z","timestamp":1633350467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between adiponectin\u2010to\u2010leptin ratio and heart rate variability in new\u2010onset paroxysmal atrial fibrillation: A retrospective cohort study"],"prefix":"10.1111","volume":"27","author":[{"given":"Tongjian","family":"Zhu","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Cardiology Department of Cardiology Renmin Hospital of Wuhan University Cardiovascular Research Institute Wuhan University  Wuhan China"},{"name":"Department of Cardiology Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Cardiology Department of Cardiology Renmin Hospital of Wuhan University Cardiovascular Research Institute Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Cardiology Department of Cardiology Renmin Hospital of Wuhan University Cardiovascular Research Institute Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Cardiology Department of Cardiology Renmin Hospital of Wuhan University Cardiovascular Research Institute Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7435-1730","authenticated-orcid":false,"given":"Kezhong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science  Xiangyang 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