{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:47:21Z","timestamp":1791856041179,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The analysis of heart rate variability (HRV) and heart rate (HR) dynamics by Holter ECG has been standardized to 24\u00a0hs, but longer\u2010term continuous ECG monitoring has become available in clinical practice. We investigated the effects of long\u2010term ECG on the assessment of HRV and HR dynamics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Intraweek variations in HRV and HR dynamics were analyzed in 107 outpatients with sinus rhythm. ECG was recorded continuously for 7\u00a0days with a flexible, codeless, waterproof sensor attached on the upper chest wall. Data were divided into seven 24\u2010h segments, and standard time\u2010 and frequency\u2010domain HRV and nonlinear HR dynamics indices were computed for each segment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The intraweek coefficients of variance of HRV and HR dynamics indices ranged from 2.9% to 26.0% and were smaller for frequency\u2010domain than for time\u2010domain indices, and for indices reflecting slower HR fluctuations than faster fluctuations. The indices with large variance often showed transient abnormalities from day to day over 7\u00a0days, reducing the positive predictive accuracy of the 24\u2010h ECG for detecting persistent abnormalities over 7\u00a0days. Conversely, 7\u2010day ECG provided 2.3\u2010 to 6.5\u2010fold increase in sensitivity to detect persistent plus transient abnormalities compared with 24\u2010h ECG. It detected an average of 1.74 to 2.91 times as many abnormal indices as 24\u2010h ECG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term ECG monitoring increases the accuracy and sensitivity of detecting persistent and transient abnormalities in HRV and HR dynamics and allows discrimination between the two types of abnormalities. Whether this discrimination improves risk stratification deserves further studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12897","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T12:44:37Z","timestamp":1632228277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Enhanced detection of abnormalities in heart rate variability and dynamics by 7\u2010day continuous ECG monitoring"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5340-6325","authenticated-orcid":false,"given":"Junichiro","family":"Hayano","sequence":"first","affiliation":[{"name":"Heart Beat Science Lab, Co., Ltd. Sendai Japan"},{"name":"Nagoya City University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Yuda","sequence":"additional","affiliation":[{"name":"Heart Beat Science Lab, Co., Ltd. Sendai Japan"},{"name":"Center for Data\u2010driven Science and Artificial Intelligence Tohoku University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68735-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.23.3106"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.1.164"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.12.2142"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.003333"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"issue":"3","key":"e_1_2_11_8_1","first-page":"251","article-title":"Comparison of arrhythmia detection by 24\u2010h holter and 14\u2010day continuous electrocardiography patch monitoring","volume":"36","author":"Chua S. 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