{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:21:58Z","timestamp":1791667318079,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T00:00:00Z","timestamp":1635033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>QT interval represents the ventricular depolarization and repolarization. Its accurate measurement is critical since prolonged QT can lead to sudden cardiac death. QT is affected by heart rate and is corrected to QTc via several formulae. QTc is commonly calculated on the ECG and not the 24\u2010h Holter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>100 patients presenting to our institution were evaluated by an ECG followed by a 24\u2010h Holter. QTc measurement on both platforms using Bazett and Fridericia formulae was recorded and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 14.09\u00a0years, with the majority being males. Mean heart rate was 125.87. In the ECG, the mean QTc interval via the Bazett formula was 0.40\u00a0s compared with 0.38\u00a0s using the Fridericia formula. The mean corrected QT via the Bazett formula was 0.45, 0.39, and 0.42\u00a0s for the shortest RR, the longest RR, and the average RR, respectively. In contrast to the Fridericia formula, the corrected QT interval was 0.40, 0.39, and 0.40\u00a0s for the shortest RR, the longest RR, and the average RR, respectively. Using the Bazett formula, the highest specificity was reached during the longest RR interval (92.2%), while the highest sensitivity was recorded during the shortest RR interval (40%). As for the Fridericiaformula, sensitivity always reached 0%, while the highest specificity was reached during the average RR interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>QTc measured during Holter ECG reached a high specificity regardless of RR interval using the Fridericia and during the longest and the average RR interval for the Bazett formula. The consistently low sensitivity reveals that Holter ECG should not be used to rule out prolonged QT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12899","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T14:49:55Z","timestamp":1635086995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["QTc interval on 24\u2010hour holter monitor: To trust or not to trust?"],"prefix":"10.1111","volume":"27","author":[{"given":"Mhd Khalil","family":"Tamr Agha","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine Department of Pediatrics Children\u2019s Mercy Kansas City Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghina","family":"Fakhri","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics and Adolescent Medicine American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Family Medicine American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"El Sedawy","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics and Adolescent Medicine American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Abi Saleh","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Bitar","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics and Adolescent Medicine American University of 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