{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:14:54Z","timestamp":1783098894485,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In the PRESERVE\u2010EF study, a two\u2010step sudden cardiac death (SCD) risk stratification approach to detect post\u2010myocardial infarction (MI) patients with left ventricle ejection fraction (LVEF) \u226540% at risk for major arrhythmic events (MAEs) was used. Seven noninvasive risk factors (NIRFs) were extracted from a 24\u2010h ambulatory electrocardiography (AECG) and a 45\u2010min resting recording. Patients with at least one NIRF present were referred for invasive programmed ventricular stimulation (PVS) and inducible patients received an Implantable Cardioverter \u2010 Defibrillator (ICD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present study, we evaluated the performance of the NIRFs, as they were described in the PRESERVE\u2010EF study protocol, in predicting a positive PVS. In the PRESERVE\u2010EF study, 152 out of 575 patients underwent PVS and 41 of them were inducible. For the present analysis, data from these 152 patients were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the NIRFs examined, the presence of signal averaged ECG\u2010late potentials (SAECG\u2010LPs)\u00a0\u2265\u00a02\/3 and non\u2010sustained ventricular tachycardia (NSVT)\u00a0\u22651\u00a0eposode\/24\u00a0h cutoff points were important predictors of a positive PVS study, demonstrating in the logistic regression analysis odds ratios 2.285 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.027) and 2.867 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.006), respectively. A simple risk score based on the above cutoff points in combination with LVEF\u00a0&lt;\u00a050% presented high sensitivity but low specificity for a positive PVS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cutoff points of NSVT\u00a0\u2265\u00a01\u00a0episode\/24\u00a0h and SAECG\u2010LPs\u00a0\u2265\u00a02\/3 in combination with a LVEF\u00a0&lt;\u00a050% were important predictors of inducibility. However, the final decision for an ICD implantation should be based on a positive PVS, which is irreplaceable in risk stratification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12908","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T07:17:34Z","timestamp":1638861454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Noninvasive risk factors for the prediction of inducibility on programmed ventricular stimulation in post\u2010myocardial infarction patients with an ejection fraction \u226540% at risk for sudden cardiac arrest: Insights from the PRESERVE\u2010EF study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4789-9688","authenticated-orcid":false,"given":"Konstantinos","family":"Trachanas","sequence":"first","affiliation":[{"name":"State Department of Cardiology Hippokrateion General Hospital  Athens 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