{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:26:45Z","timestamp":1753878405684,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The inSighT study was designed to determine the prevalence of ischemic changes as recorded by implantable cardioverter\u2013defibrillator (ICD) ST deviations in intracardiac electrocardiograms (EGM) over the 24\u00a0h preceding malignant ventricular arrhythmias (VT\/VF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study enrolled patients with known coronary artery disease (CAD) or high risk of future development of CAD implanted with an ICD equipped with an ST monitoring feature (Ellipse\u2122\/Fortify Assura\u2122, St. Jude Medical). Device session records were collected at each in\u2010clinic follow\u2010up. EGM ST levels of the beats over the 15\u00a0minutes prior to VT\/VF events were compared using a t test with those from a baseline period of 23\u201324\u00a0h prior to the VT\/VF event. All events with <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05 were visually inspected to confirm they were evaluable; additional criteria for exclusion from further analysis included inappropriate therapy, aberrant conduction, and occurrence of VT\/VF within 24h prior to the current event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study enrolled 481 ICD patients (64 \u00b1\u00a011\u00a0years, 83% male) in 14 countries and followed them for 15\u00b15\u00a0months. A total of 165 confirmed VT\/VF episodes were observed, of which 71 events (in 56 patients, 34% of all patients with VT\/VF) were preceded by significant (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) ST\u2010segment changes unrelated to known non\u2010ischemic causes. None of the analyzed demographic and clinical factors proved to be associated with greater odds of presenting with ST\u2010segment changes prior to VT\/VF episode.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this exploratory study, characteristic ST\u2010segment changes, likely representative of ischemic events, were observed in 34% of all patients with VT\/VF episodes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12914","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T08:01:28Z","timestamp":1644998488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical valuation of ST changes in a group of patients with ventricular arrhythmias: The inSighT Study"],"prefix":"10.1111","volume":"27","author":[{"given":"Jerzy Krzysztof","family":"Wranicz","sequence":"first","affiliation":[{"name":"Department of Electrocardiology Medical University of Lodz  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