{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:59:46Z","timestamp":1787317186125,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Brugada syndrome (BrS) is somewhat a challenging diagnosis, due to its dynamic pattern. One of the aspects of this disease is a significant conduction disorder located in the right ventricular outflow tract (RVOT), which can be explained as a consequence of low expression of Connexin\u201043. This decreased conduction speed is responsible for the typical electrocardiographic pattern. Opposite leads located preferably in inferior leads of the electrocardiogram may show a deep and widened S wave associated with ascending ST segment depression. Holter monitoring electrocardiographic (ECG) aspects is still a new frontier of knowledge in BrS, especially in intermittent clinical presentations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We describe, as an exploratory analysis, five case series of intermittent type 1 BrS to demonstrate the appearance of ascending ST segment depression and widening of the S wave, during 3\u2010channel 24h\u2010Holter monitoring (C1, C2 and C3) with bipolar leads.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the five cases described, the ST segment depression was observed mainly in C2, but in some cases also in C1 and C3. Only case 1 presented concomitant intermittent elevation of the ST segment in C1. All cases were intermittent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The recognition of an ECG pattern with ascending ST\u2010segment depression and widening of the S wave in 3\u2010channel Holter described in this case series should raise a suspicion of the BrS and suggests the counterpart of a dromotropic disturbance registered in the RVOT and\/or reciprocal changes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anec.12917","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T10:45:51Z","timestamp":1639046751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transient ascending ST\u2010segment depression and widening of the S wave in 3\u2010channel Holter monitoring\u2014A sign of dromotropic disturbance in the right ventricular outflow tract in the Brugada syndrome: A report of five cases"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1494-8981","authenticated-orcid":false,"given":"Antonio Thomaz","family":"de Andrade","sequence":"first","affiliation":[{"name":"Hospital de Messejana Dr. Carlos Alberto Studart Gomes  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5113-3116","authenticated-orcid":false,"given":"Raimundo","family":"Barbosa\u2010Barros","sequence":"additional","affiliation":[{"name":"Hospital de Messejana Dr. Carlos Alberto Studart Gomes  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9345-9851","authenticated-orcid":false,"given":"Kjell","family":"Nikus","sequence":"additional","affiliation":[{"name":"Heart Center Tampere University Hospital and Faculty of Medicine and Health Technology Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3043-0728","authenticated-orcid":false,"given":"Rodrigo D.","family":"Raimundo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Delineamento de Estudos e Escrita Cient\u00edfica Centro Universit\u00e1rio FMABC Centro Universit\u00e1rio FMABC  Santo Andr\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7618-2109","authenticated-orcid":false,"given":"Luiz C.","family":"de Abreu","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Delineamento de Estudos e Escrita Cient\u00edfica Centro Universit\u00e1rio FMABC Centro Universit\u00e1rio FMABC  Santo Andr\u00e9 Brazil"},{"name":"Universidade Federal do Esp\u00edrito Santo Departamento de Educa\u00e7\u00e3o Integrada em Sa\u00fade UFES  Vit\u00f3ria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3679-5349","authenticated-orcid":false,"given":"Luciana","family":"Sacilotto","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5818-5958","authenticated-orcid":false,"given":"Francisco C. C.","family":"Darriuex","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8989-022X","authenticated-orcid":false,"given":"Frank G.","family":"Yanowitz","sequence":"additional","affiliation":[{"name":"University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3172-6106","authenticated-orcid":false,"given":"Pedro","family":"Brugada","sequence":"additional","affiliation":[{"name":"University Hospital of Brussel (UZ Brussel\u2010VUB)  Jette Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-538X","authenticated-orcid":false,"given":"Andr\u00e9s Ricardo","family":"P\u00e9rez\u2010Riera","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Delineamento de Estudos e Escrita Cient\u00edfica Centro Universit\u00e1rio FMABC Centro Universit\u00e1rio FMABC  Santo Andr\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.HRTHM.2007.04.017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.06.037"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.01.024"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.10.007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12247"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.02.026"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.033"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.68.1018"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2020.07.037"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut272"}],"container-title":["Annals of Noninvasive Electrocardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.12917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anec.12917","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.12917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T19:22:03Z","timestamp":1692559323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/anec.12917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,9]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/anec.12917"],"URL":"https:\/\/doi.org\/10.1111\/anec.12917","archive":["Portico"],"relation":{},"ISSN":["1082-720X","1542-474X"],"issn-type":[{"value":"1082-720X","type":"print"},{"value":"1542-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,9]]},"assertion":[{"value":"2021-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12917"}}