{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:20:35Z","timestamp":1772000435090,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T00:00:00Z","timestamp":1645315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2019\u2010I2M\u20102\u2010003"],"award-info":[{"award-number":["2019\u2010I2M\u20102\u2010003"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000470"],"award-info":[{"award-number":["82000470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammatory cardiomyopathy (IC) is a syndrome with chronic myocarditis and cardiac remodeling. This study aimed to explore predicting factors of adverse outcomes in patients with IC secondary to idiopathic inflammatory myopathy (IIM\u2010IC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>By means of a single\u2010center retrospective study, 52 patients with IIM\u2010IC at Peking Union Medical College Hospital were identified from January 1999 to June 2019. Electrocardiogram and echocardiography data were analyzed for the primary outcome (defined as all\u2010cause death) and secondary outcomes (defined as re\u2010hospitalization of heart failure and all\u2010cause death), using regression and survival analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of atrial fibrillation, ventricular tachycardia, Q\u2010wave abnormality, left ventricular conduction abnormalities, and reduced left ventricular ejection fraction (LVEF) (\u226440%) were 65.4%, 67.3%, 67.3%, 61.6%, and 50.5%. After a median follow\u2010up of 2\u00a0years (IQR 0.8\u20133.0), 26 cases were readmitted due to heart failure. Twenty\u2010two deaths were recorded, including 20 cardiogenic deaths. Among the patients with adverse events, the incidence of poor R\u2010wave progression, low\u2010voltage of the limb leads, Q\u2010wave abnormality, QRS duration &gt;130\u00a0ms, left ventricular enlargement, and impaired systolic function were higher. Kaplan\u2013Meier analysis showed that Q\u2010wave abnormality, limb leads low\u2010voltage, LVEF \u226440%, and left ventricular end\u2010diastolic dimension &gt;60\u00a0mm were correlated with shorter survival. However, multivariate Cox regression analysis revealed that only Q\u2010wave abnormality (<jats:italic>HR<\/jats:italic>\u00a0=\u00a012.315) and LVEF \u226440% (<jats:italic>HR<\/jats:italic>\u00a0=\u00a05.616) were independent risk factors for all\u2010cause death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Q\u2010wave abnormality and reduced LVEF are predictive of poor prognosis in patients with IIM\u2010IC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12938","type":"journal-article","created":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T17:09:20Z","timestamp":1645376960000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Electrophysiological, structural, and functional disorders in patients with inflammatory cardiomyopathy secondary to inflammatory myopathy"],"prefix":"10.1111","volume":"27","author":[{"given":"Yingxian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanlin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuwei","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3980-3682","authenticated-orcid":false,"given":"Ligang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht210"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"3","article-title":"Myocarditis: A histopathologic definition and classification","volume":"1","author":"Aretz H. 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