{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:14:21Z","timestamp":1783098861700,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Electrocardiographic non\u2010invasive risk factors (NIRFs) have an important role in the arrhythmic risk stratification of post\u2010myocardial infarction (post\u2010MI) patients with preserved or mildly reduced left ventricular ejection fraction (LVEF). However, their specific relation to left ventricular systolic function remains unclear. We aimed to evaluate the association between NIRFs and LVEF in the patients included in the PRESERVE\u2010EF trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 575 post\u2010MI ischemia\u2010free patients with LVEF\u226540% (mean age: 57.0\u00a0\u00b1\u00a010.4\u00a0years, 86.2% men). The following NIRFs were evaluated: premature ventricular complexes, non\u2010sustained ventricular tachycardia (NSVT), late potentials (LPs), prolonged QTc, increased T\u2010wave alternans, reduced heart rate variability, and abnormal deceleration capacity with abnormal turbulence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a statistically significant relationship between LPs (Chi\u2010squared\u00a0=\u00a04.975; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.05), nsVT (Chi\u2010squared\u00a0=\u00a05.749, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), PVCs (<jats:italic>r<\/jats:italic>=\u00a0\u2212.136; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01), and the LVEF. The multivariate linear regression analysis showed that LPs (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001) and NSVT (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) were significant predictors of the LVEF. The results of the multivariate logistic regression analysis indicated that LPs (OR: 1.76; 95% CI: 1.02\u20133.05; <jats:italic>p\u00a0<\/jats:italic>=\u00a0.004) and NSVT (OR: 2.44; 95% CI: 1.18\u20135.04; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001) were independent predictors of the mildly reduced LVEF: 40%\u201349% versus the preserved LVEF: \u226550%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Late potentials and NSVT are independently related to reduced LVEF while they are independent predictors of mildly reduced LVEF versus the preserved LVEF. These findings may have important implications for the arrhythmic risk stratification of post\u2010MI patients with mildly reduced or preserved LVEF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12946","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T06:44:16Z","timestamp":1657176256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of non\u2010invasive electrocardiographic risk factors with left ventricular systolic function in post\u2010myocardial infarction patients with mildly reduced or preserved ejection fraction: Insights from the PRESERVE\u2010EF study"],"prefix":"10.1111","volume":"27","author":[{"given":"Konstantinos P.","family":"Tsimos","sequence":"first","affiliation":[{"name":"First Department of Cardiology University of Ioannina Medical School  Ioannina 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National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Tsiachris","sequence":"additional","affiliation":[{"name":"First Department of Cardiology Hippokrateion Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6628-0303","authenticated-orcid":false,"given":"Christos\u2010Konstantinos","family":"Antoniou","sequence":"additional","affiliation":[{"name":"First Department of Cardiology Hippokrateion Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Krikonis","sequence":"additional","affiliation":[{"name":"DatAnalysis  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skevos","family":"Sideris","sequence":"additional","affiliation":[{"name":"State Department of Cardiology Hippokrateion General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-4111","authenticated-orcid":false,"given":"Polychronis","family":"Dilaveris","sequence":"additional","affiliation":[{"name":"First Department of Cardiology Hippokrateion Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6117-2389","authenticated-orcid":false,"given":"Konstantinos","family":"Triantafyllou","sequence":"additional","affiliation":[{"name":"Third Department of Cardiology Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4150-5286","authenticated-orcid":false,"given":"Stergios","family":"Soulaidopoulos","sequence":"additional","affiliation":[{"name":"First Department of Cardiology Hippokrateion Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Kanoupakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology School of Medicine Heraklion University Hospital University of Crete  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Fragakis","sequence":"additional","affiliation":[{"name":"Third Department of Cardiology Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Sideris","sequence":"additional","affiliation":[{"name":"Second State Department of Cardiology Evangelismos Athens General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Trachanas","sequence":"additional","affiliation":[{"name":"State Department of Cardiology Hippokrateion General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios","family":"Iliodromitis","sequence":"additional","affiliation":[{"name":"Second Cardiology Department Attikon Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Tousoulis","sequence":"additional","affiliation":[{"name":"First Department of Cardiology Hippokrateion Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Tsioufis","sequence":"additional","affiliation":[{"name":"First Department of Cardiology Hippokrateion Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theofilos M.","family":"Kolettis","sequence":"additional","affiliation":[{"name":"First Department of Cardiology 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