{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:23:59Z","timestamp":1753878239052,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atrial pacing and right ventricular (RV) pacing are both associated with adverse outcomes among patients with first\u2010degree atrioventricular block (1\u00b0AVB). His\u2010bundle pacing (HBP) provides physiological activation of the ventricle and may be able to improve both atrioventricular (AV) and inter\u2010ventricular synchrony in 1\u00b0AVB patients. This study evaluates the acute echocardiographic and hemodynamic effects of atrial, atrial\u2010His\u2010bundle sequential (AH), and atrial\u2010ventricular (AV) sequential pacing in 1\u00b0AVB patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with 1\u00b0AVB undergoing atrial fibrillation ablation were included. Following left atrial (LA) catheterization, patients underwent atrial, AH\u2010 and AV\u2010sequential pacing. LA\/left ventricular (LV) pressure and echocardiographic measurements during the pacing protocols were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen patients with 1\u00b0AVB (mean PR 221\u00a0\u00b1\u00a026\u00a0ms) were included. The PR interval was prolonged with atrial pacing compared to baseline (275\u00a0\u00b1\u00a073\u00a0ms, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.005). LV ejection fraction (LVEF) was highest during atrial pacing (62\u00a0\u00b1\u00a011%), intermediate with AH\u2010sequential pacing (59\u00a0\u00b1\u00a07%), and lowest with AV\u2010sequential pacing (57\u00a0\u00b1\u00a012%) though these differences were not statistically significant. No significant differences were found in LA or LV mean pressures or LV dP\/dT. LA and LV volumes, isovolumetric times, electromechanical delays, and global longitudinal strains were similar across pacing protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite pronounced PR prolongation, the acute effects of atrial pacing were not significantly different than AH\u2010 or AV\u2010sequential pacing. Normalizing atrioventricular and\/or inter\u2010ventricular dyssynchrony did not result in acute improvements in cardiac output or loading conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.12954","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T07:39:54Z","timestamp":1650526794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute echocardiographic and hemodynamic response to his\u2010bundle pacing in patients with first\u2010degree atrioventricular block"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4613-582X","authenticated-orcid":false,"given":"Zak","family":"Loring","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine Duke University  Durham North Carolina USA"},{"name":"Duke Clinical Research Institute  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5369-1296","authenticated-orcid":false,"given":"Fredrik","family":"Holmqvist","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Duke University  Durham North Carolina USA"},{"name":"Department of Cardiology Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Sze","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Duke University  Durham North Carolina USA"},{"name":"Maine Medical Center  Portland Maine USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fawaz","family":"Alenezi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Campbell","sequence":"additional","affiliation":[{"name":"Maine Medical Center  Portland Maine USA"},{"name":"Department of Pharmacy Duke University Medical Center  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason I.","family":"Koontz","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Velazquez","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Duke University  Durham North Carolina USA"},{"name":"Section of Cardiovascular Medicine Department of Internal Medicine Yale University  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett D.","family":"Atwater","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Duke University  Durham North Carolina USA"},{"name":"Section of Cardiac Electrophysiology Inova Heart and Vascular Institute  Fairfax Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tristram D.","family":"Bahnson","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9616-9219","authenticated-orcid":false,"given":"James P.","family":"Daubert","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.048"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.04.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20100736(77)80005\u20108"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.08.038"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.06.016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.03.005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr139"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102125.1990.tb03803.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.8.869"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022913"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12062"},{"key":"e_1_2_9_13_1","first-page":"93","volume-title":"Josephson\u2019s clinical cardiac electrophysiology","author":"Josephson M. 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