{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:01:28Z","timestamp":1785841288419,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Conventional Doppler measurements have limitations in predicting left ventricular diastolic dysfunction (LVDD) in patients with mitral regurgitation (MR). Recently, electrocardiographic P\u2010wave peak time (PWPT) has been proposed as a parameter of detecting LVDD. This study aimed to evaluate the association between PWPT and left ventricular end\u2010diastolic pressure (LVEDP) in patients with MR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed echocardiography and cardiac catheterization in 82 patients with moderate or severe MR. We classified patients into two groups: low LVEDP group (L\u2010LVEDP) (LVEDP &lt;16\u2009mmHg, <jats:italic>n<\/jats:italic>\u00a0=\u00a040) and high LVEDP group (H\u2010LVEDP) (LVEDP \u226516\u2009mmHg, <jats:italic>n<\/jats:italic>\u00a0=\u00a042). We evaluated LVDD and PWPT based on echocardiographic and electrocardiographic findings in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PWPT in lead II (PWPT<jats:sub>II<\/jats:sub>) was significantly longer in patients in the H\u2010LVEDP group than in those in the L\u2010LVEDP group (67 vs. 47\u2009ms, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Using correlation analysis, LVEDP was positively correlated with PWPT<jats:sub>II<\/jats:sub> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.577, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Using multivariate analysis, PWPT<jats:sub>II<\/jats:sub> was found to be an independent predictor of increased LVEDP (95% CI: 0.1030\u20130.110; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Using receiver operating characteristic (ROC) curve analysis, the optimal cutoff value of PWPT<jats:sub>II<\/jats:sub> for predicting elevated LVEDP was 58.9\u00a0ms, with a sensitivity of 80.0% and a specificity of 73.8% (area under curve: 0.809, 95% CI: 0.713\u20130.905).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To the best of our knowledge, this is the first study to assess the effect of a significant valvular disease on PWPT in lead II. These findings suggest that prolonged PWPT<jats:sub>II<\/jats:sub> may be an independent predictor of increased LVEDP in patients with moderate or severe MR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.13000","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T16:03:45Z","timestamp":1660665825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Usefulness of P\u2010wave peak time as an electrocardiographic parameter in predicting left ventricular diastolic dysfunction in patients with mitral regurgitation"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1168-495X","authenticated-orcid":false,"given":"Kazuki","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Cardiology Seirei Mikatahara General Hospital  Hamamatsu\u2010City, Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5999-7747","authenticated-orcid":false,"given":"Keisuke","family":"Miyajima","sequence":"additional","affiliation":[{"name":"Department of Cardiology Seirei Mikatahara General Hospital  Hamamatsu\u2010City, Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Urushida","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hamamatsu University School of Medicine  Hamamatsu\u2010City, Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Unno","sequence":"additional","affiliation":[{"name":"Department of Cardiology Seirei Mikatahara General Hospital  Hamamatsu\u2010City, Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Seirei Mikatahara General Hospital  Hamamatsu\u2010City, Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyo","family":"Takashima","sequence":"additional","affiliation":[{"name":"Department of Cardiology Seirei Mikatahara General Hospital  Hamamatsu\u2010City, Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology Seirei Mikatahara General Hospital  Hamamatsu\u2010City, Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Seirei Mikatahara General Hospital  Hamamatsu\u2010City, Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Seirei Mikatahara General Hospital  Hamamatsu\u2010City, Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hamamatsu University School of Medicine  Hamamatsu\u2010City, Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40119\u2010019\u20100134\u20105"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.21542\/gcsp.2017.3"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00059\u2010019\u201004859\u20101"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.1025"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.177303"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.954388"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.03.108"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.10.012"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13530"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2019.05.015"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2017.06.010"},{"key":"e_1_2_14_13_1","first-page":"53","article-title":"Mitral regurgitation: Basic pathophysiologic principles","volume":"57","author":"Carabello B. 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