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We report a 20\u2010year\u2010old patient without sustained tachyarrhythmia with a left ventricular ejection fraction of 20% who underwent radiofrequency catheter ablation (RFCA) of anteroseptal accessory pathway. She achieved normalization of left ventricular systolic function noted on echocardiography performed at 4\u2009weeks post\u2010ablation. Our case highlights significant improvement in LV systolic function after catheter ablation of an \u201casymptomatic\u201d ventricular pre\u2010excitation. Current guidelines do not endorse ablating asymptomatic patients, but careful follow\u2010up with serial echocardiograms might be warranted. Prophylactic ablation of those patients with clear evidence of LV dyssynchrony or wide left bundle branch pattern and persistent pre\u2010excitation is worth further consideration.<\/jats:p>","DOI":"10.1111\/anec.13001","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T10:46:09Z","timestamp":1659955569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Resolution of severe cardiomyopathy after catheter ablation of an anteroseptal accessory pathway: A case report"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6090-2028","authenticated-orcid":false,"given":"Omar J.","family":"Baqal","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vatsal M.","family":"Ladia","sequence":"additional","affiliation":[{"name":"Self Regional Healthcare  Greenwood South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2470-2862","authenticated-orcid":false,"given":"Hicham","family":"El Masry","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"695","article-title":"Tachycardia\u2010mediated cardiomyopathy and the permanent form of junctional reciprocating tachycardia","volume":"37","author":"Bensler J.","year":"2010","journal-title":"Texas Heart Institute Journal"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-2070-z"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e3280103994"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951104006031"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.11.109"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccase.2016.10.002"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2009.01612.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2020.01.012"},{"key":"e_1_2_11_10_1","first-page":"1217","article-title":"Heart failure in a patient with Wolff\u2010Parkinson\u2010White syndrome","volume":"64","author":"Marti\u2010Almor J.","year":"2011","journal-title":"Revista Espa\u00f1ola de Cardiolog\u00eda"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035345"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02706-7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joa.2014.03.011"},{"key":"e_1_2_11_14_1","first-page":"248","article-title":"Dyssynchronous ventricular activation in asymptomatic Wolff\u2013Parkinson\u2013white syndrome: A risk factor for development of dilated cardiomyopathy","volume":"10","author":"Ten Cate F. 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