{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:24:09Z","timestamp":1753878249016,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R61HL153001\u201001A1"],"award-info":[{"award-number":["1R61HL153001\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Percutaneous catheter ablation (CA) to achieve pulmonary vein isolation is an effective treatment for drug\u2010refractory paroxysmal and persistent atrial fibrillation (AF). However, recurrence rates after a single AF ablation procedure remain elevated. Conventional management after CA ablation has mostly been based on clinical AF recurrence. However, continuous recordings with insertable cardiac monitors (ICMs) and patient\u2010triggered mobile app transmissions post\u2010CA can now be used to detect early recurrences of subclinical AF (SCAF). We hypothesize that early intervention following CA based on personalized ICM data can prevent the substrate progression that promotes the onset and maintenance of atrial arrhythmias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a randomized, double\u2010blind (to SCAF data), single\u2010tertiary center clinical trial in which 120 patients with drug\u2010refractory paroxysmal or persistent AF are planned to undergo CA with an ICM. Randomization will be to <jats:italic>an intervention arm<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a060) consisting of ICM\u2010guided early intervention based on SCAF and patient\u2010triggered mobile app transmissions versus <jats:italic>a control arm<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a060) consisting of a standard intervention protocol based on clinical AF recurrence validated by the ICM. Primary endpoint is AF burden, which will be assessed from ICMs at 15\u2009months post\u2010AF ablation. Secondary endpoints include healthcare utilization, functional capacity, and quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We believe that ICM\u2010guided early intervention will provide a novel, personalized approach to post\u2010AF ablation management that will result in a significant reduction in AF burden, healthcare utilization, and improvements in functional capacity and quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.13043","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T10:39:12Z","timestamp":1675161552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Insertable cardiac monitor\u2010guided early intervention to reduce atrial fibrillation burden following catheter ablation: Study design and clinical protocol (<scp>ICM\u2010REDUCE\u2010AF<\/scp> trial)"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9317-5509","authenticated-orcid":false,"given":"Sinan S.","family":"Tankut","sequence":"first","affiliation":[{"name":"Division of Cardiology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Zareba","sequence":"additional","affiliation":[{"name":"Clinical Cardiovascular Research Center University of Rochester Medical Center  Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9003-9384","authenticated-orcid":false,"given":"Mehmet K.","family":"Aktas","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer Z.","family":"Rosero","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Clinical Cardiovascular Research Center University of Rochester Medical Center  Rochester New York USA"},{"name":"Summit Medical Group  Short Hills New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Henchen","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Kutyifa","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Strawderman","sequence":"additional","affiliation":[{"name":"Clinical Cardiovascular Research Center University of Rochester Medical Center  Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Clinical Cardiovascular Research Center University of Rochester Medical Center  Rochester New York 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