{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:18:06Z","timestamp":1753877886551,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Left ventricular (LV) lead position may be an important factor for delivering effective cardiac resynchronization therapy (CRT). We therefore aimed to evaluate the effects of LV lead position, stratified by native QRS morphology, regarding the clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1295 CRT\u2010implanted patients were retrospectively evaluated. LV lead position was classified as lateral, anterior, inferior, or apical, and was determined using the left and right anterior oblique X\u2010ray views. Kaplan Meier and Cox regression were performed to evaluate the effects on all\u2010cause mortality and heart failure hospitalization, and the potential interaction between LV lead position and native ECG morphologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1295 patients were included. Patients were aged 69\u2009\u00b1\u20097\u2009years, 20% were female, 46% received a CRT\u2010Pacemaker (vs. CRT\u2010Defibrillator), mean LVEF was 25%\u2009\u00b1\u20097%, and median follow\u2010up was 3.3\u2009years [IQR 1.6\u20135\u20137\u2009years]. Eight hundred and eighty\u2010two patients (68%) had a lateral LV lead location, 207 (16%) anterior, 155 (12%) apical, and 51 (4%) inferior. Patients with lateral LV lead position had larger QRS reduction (\u221213\u2009\u00b1\u200927\u2009ms vs. \u22123\u2009\u00b1\u200924\u2009ms, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Non\u2010lateral lead location was associated with a higher risk for all\u2010cause mortality (HR 1.34 [1.09\u20131.67], <jats:italic>p<\/jats:italic>\u2009=\u2009.007) and heart failure hospitalization (HR 1.25 [1.03\u20131.52], <jats:italic>p<\/jats:italic>\u2009=\u2009.03). This association was strongest for patients with native left or right bundle branch block, and not significant for patients with prior paced QRS or nonspecific intraventricular conduction delay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients treated with CRT, non\u2010lateral LV lead positions (including apical, anterior, and inferior positions) were associated with worse clinical outcome and less reduction of QRS duration. This association was strongest for patients with native LBBB or RBBB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.13065","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:58:42Z","timestamp":1684432722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between left ventricular lead position and intrinsic <scp>QRS<\/scp> morphology with regard to clinical outcome in cardiac resynchronization therapy for heart failure"],"prefix":"10.1111","volume":"28","author":[{"given":"Tove Olsson","family":"Brandtvig","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Department of Cardiology, Arrhythmia Section Skane University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Marinko","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Department of Cardiology, Arrhythmia Section Skane University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiwand","family":"Farouq","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Department of Cardiology, Arrhythmia Section Skane University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Department of Cardiology, Arrhythmia Section Skane University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2485-6044","authenticated-orcid":false,"given":"David","family":"M\u00f6rtsell","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund 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