{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:27:01Z","timestamp":1753878421176,"version":"3.41.2"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to retrospectively assess cardiac autonomic activity in children with LQTS, considering genotype, symptoms, sex, age, and beta\u2010blocker therapy (BB) and compare it to healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Heart rate variability (HRV), using power spectrum analysis, was analyzed in 575 Holter recordings from 116 children with LQTS and in 69 healthy children. The data were categorized into four age\u2010groups and four heart rate (HR) ranges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In LQT1 and LQT2, increasing HR corresponded to significantly lower low (LF) and high frequency (HF) compared to controls. Total power (PTOT) was lower in all LQT1 age\u2010groups compared to controls at HR 120\u2013140\u2009bpm (1\u201315\u2009years: <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01; 15\u201318\u2009years: <jats:italic>p<\/jats:italic>\u2009=\u2009.03). At HR 80\u2013100, LQT1 patients aged 1\u201310\u2009years had lower HF than LQT2 patients (1\u20135\u2009years: <jats:italic>p<\/jats:italic>\u2009=\u2009.05; 5\u201310\u2009years: <jats:italic>p<\/jats:italic>\u2009=\u2009.02), and LQT2 patients aged 15\u201318\u2009years had lower HF than LQT1 patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Symptomatic patients aged 10\u201315\u2009years had lower PTOT at HR 100\u2013120\u2009bpm than asymptomatic patients (<jats:italic>p<\/jats:italic>\u2009=\u2009.04). LQT1 girls aged 10\u201315 and 15\u201318\u2009years had a lower PTOT (10\u201315\u2009years: <jats:italic>p<\/jats:italic>\u2009=\u2009.04; 15\u201318\u2009years: <jats:italic>p<\/jats:italic>\u2009=\u2009.02) than boys.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows a correlation between HR and changes in HRV parameters. At higher HRs, LQTS patients generally had lower HRV values than controls, suggesting an abnormal autonomic response. These results may strengthen the link between physical activity and arrhythmias in LQTS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.13132","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T12:01:22Z","timestamp":1718712082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Holter study of heart rate variability in children and adolescents with long <scp>QT<\/scp> syndrome"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7826-1804","authenticated-orcid":false,"given":"Anna","family":"Lundstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5kan","family":"Eliasson","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Intervention, Biomedical Engineering and Radiation Physics Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urban","family":"Wiklund","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Intervention, Biomedical Engineering and Radiation Physics Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Rydberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6166045"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euq408"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj\u201011\u20101052"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246\u2010003\u20100567\u20103"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840\u2010012\u20109728\u20108"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.046"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2020.102723"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1875"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/circep.113.000514"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109149(91)90445\u2010q"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.10.1249"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u2010925x\u201011\u20102"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12537"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.103.16.2072"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.97.22.2237"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2021.102897"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014868"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540\u20108159.2011.03102.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.114.03782"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.60.742"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.6.616"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.59.2.178"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542\u2010474x.2001.tb00122.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1985.248.1.H151"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.11.015"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv316"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.03.038"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.103.1.89"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.069"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000066284.34258.59"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0970585"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.116.08053"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/circep.116.004645"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2017.07.012"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.1951"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735\u20101097(95)60383\u20102"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0735\u20101097(03)00554\u20100"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199810013391404"}],"container-title":["Annals of Noninvasive Electrocardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.13132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T12:52:07Z","timestamp":1722257527000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/anec.13132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,18]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/anec.13132"],"URL":"https:\/\/doi.org\/10.1111\/anec.13132","archive":["Portico"],"relation":{},"ISSN":["1082-720X","1542-474X"],"issn-type":[{"type":"print","value":"1082-720X"},{"type":"electronic","value":"1542-474X"}],"subject":[],"published":{"date-parts":[[2024,6,18]]},"assertion":[{"value":"2023-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13132"}}