{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:27:35Z","timestamp":1753878455629,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to investigate the clinical implication of incidentally induced atrial fibrillation (AF) during programmed electrical stimulation (PES) in patients with left ventricular systolic dysfunction (\u226440%) after an acute myocardial infarction (MI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we included 231 patients from the Cardiac Arrhythmias and RIsk Stratification after Myocardial InfArction (CARISMA) study with left ventricular ejection fraction \u226440% and no prior history of AF. These patients underwent PES 6\u2009weeks post\u2010MI as part of the study protocol. Patients all received an implantable cardiac monitor (ICM) 3\u201321\u2009days post\u2010MI and were continuously monitored for cardiac arrhythmias for 2\u2009years. Induction of AF was unwanted but reported if this incidentally occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 61 patients (26%) developed AF within 2\u2009years of follow\u2010up, in which <jats:italic>n<\/jats:italic>\u2009=\u200910 (29%) had incidental AF during PES at baseline. The overall risk of AF was not significantly increased in patients with incidental AF (<jats:italic>n<\/jats:italic>\u2009=\u200934) during PES compared to patients without incidental AF (<jats:italic>n<\/jats:italic>\u2009=\u2009197) (HR 1.6 [0.9\u20133.0], <jats:italic>p<\/jats:italic>\u2009=\u20090.14). The risk of bradyarrhythmia (HR\u2009=\u20090.2 [0.0\u20131.2], <jats:italic>p<\/jats:italic>\u2009=\u20090.07), ventricular arrhythmias (HR\u2009=\u20090.7 [0.1\u20135.8], <jats:italic>p<\/jats:italic>\u2009=\u20090.77), and major cardiovascular events (MACE) (HR 0.5 [0.2\u20131.7], <jats:italic>p<\/jats:italic>\u2009=\u20090.28) was not significantly different in patients with versus without incidental AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Incidentally induced AF during PES in post\u2010MI patients with reduced LVEF was not significantly associated with a higher risk of long\u2010term atrial fibrillation, other cardiac arrhythmias, or major cardiac events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>NCT00145119<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.70011","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T12:40:41Z","timestamp":1725367241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidentally Induced Atrial Fibrillation During Programmed Electrical Stimulation in Patients With Depressed Left Ventricular Systolic Function After an Acute Myocardial Infarction"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5744-7311","authenticated-orcid":false,"given":"Tharsika","family":"Sakthivel","sequence":"first","affiliation":[{"name":"Department of Cardiology Rigshospitalet University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Risum","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet University 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Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poul\u00a0Erik\u00a0Bloch","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Jons","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna\u00a0F.","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet University Hospital  Copenhagen 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