{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:47:17Z","timestamp":1791384437074,"version":"4.3.3"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n The efficacy and safety of Ivabradine for patients with acute heart failure (AHF) is controversial, and there are few clinical trials addressing this topic.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We performed this meta\u2010analysis to evaluate efficacy and safety of Ivabradine treatment for patients with acute heart failure. We obtained data for controlled trials using the PubMed, Cochrane Library, EMBASE, and Clinical\n Trials.gov<\/jats:ext-link>\n databases. The efficacy endpoints included change in heart rate, brain natriuretic peptide (BNP) levels, N\u2010terminal pro\u2010brain natriuretic peptide (NT\u2010proBNP) levels, ejection fraction (EF) values, and a 6\u2010min walk distance. The safety endpoints included mortality, cardiogenic mortality, incidents of hospital readmission, bradycardia, and atrial fibrillation. Ten randomized controlled trials (RCTs) met our criteria, and data from 656 patients were included for the study.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Ivabradine treatment significantly decreased heart rate and BNP and NT\u2010proBNP levels compared with those seen in the control group. EF values were significantly increased upon ivabradine treatment. No significant differences were observed in the endpoints of the 6\u2010min walk distance, all\u2010cause mortality, cardiogenic mortality, incidents of hospital readmission, bradycardia, and atrial fibrillation data between ivabradine treated and control groups.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Ivabradine can reduce heart rate and BNP and NT\u2010pro BNP levels and elevate EF values and 6\u2010min walk distance data significantly in acute heart failure patients. It also exhibits a stable safety profile, with similar risks of all\u2010cause mortality, cardiogenic mortality, incidents of readmission, and major adverse cardiovascular effects compared with those of the control group.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/anec.70012","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T11:13:56Z","timestamp":1729336436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and Safety of Ivabradine for Patients With Acute\u00a0Heart Failure: Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"29","author":[{"given":"Jing","family":"Han","sequence":"first","affiliation":[{"name":"Armed Police Jilin Province General Hospital Inside the Second Department Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Armed Police Jilin Province General Hospital Inside the Second Department Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lantian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Armed Police Jilin Province General Hospital Inside the Second Department Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1629-2671","authenticated-orcid":false,"given":"Xia","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261\u2010016\u20100424\u20109"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2115"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23581"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2459\/jcm.0000000000000033"},{"key":"e_1_2_11_6_1","unstructured":"Chuanrong L.2019.\u201cEffect of Different Heart Rate Control Schemes on Short\u2010Term Prognosis of Patients With Heart Failure After Admission With Reduced Ejection Fraction.\u201dDalian Medical University."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010200464160\u201000003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.079"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(14)61682\u20102"},{"issue":"4","key":"e_1_2_11_10_1","first-page":"5","article-title":"Short\u2010Term Efficacy of Ivabradine in Patients With Acute Decompensated Left Ventricular Ejection Fraction Reduction in Heart Failure","volume":"35","author":"Haiyan P.","year":"2020","journal-title":"Clinical Review"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.04.136"},{"issue":"3","key":"e_1_2_11_12_1","first-page":"15","article-title":"Effects of Ivabradine on 24h Heart Rate, Brain Natriuretic Peptide and 6\u2010Minute Walking Distance in Patients With Acute Decompensated Systolic Heart Failure","volume":"9","author":"Huaiyu G.","year":"2017","journal-title":"Chinese Journal of Evidence\u2010Based Cardiovascular Medicine"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20108703(87)90666\u20101"},{"issue":"11","key":"e_1_2_11_14_1","first-page":"10","article-title":"Efficacy and Safety of Ivabradine in the Treatment of Chronic Heart Failure","volume":"19","author":"Lixin Y.","year":"2019","journal-title":"Chinese Journal of Evidence\u2010Based Medicine"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.06.005"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2019.12.024"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.5603\/KP.a2017.0094"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed1000097"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsha.2019.05.006"},{"issue":"11","key":"e_1_2_11_20_1","first-page":"4","article-title":"Efficacy and Safety of Early Application of Ivabradine in Control of Resting Heart Rate in Patients With Acute Decompensation of Chronic Heart Failure","volume":"49","author":"Rong L.","year":"2021","journal-title":"Journal of Clinical Military Medicine"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100031\u20101281809"}],"container-title":["Annals of Noninvasive Electrocardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.70012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T06:59:48Z","timestamp":1732690788000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/anec.70012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,19]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/anec.70012"],"URL":"https:\/\/doi.org\/10.1111\/anec.70012","archive":["Portico"],"relation":{},"ISSN":["1082-720X","1542-474X"],"issn-type":[{"value":"1082-720X","type":"print"},{"value":"1542-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,19]]},"assertion":[{"value":"2024-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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