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Given the proximity of CAs to common ablation sites, understanding the interplay between RFA and CA perfusion pathophysiology is paramount. Although previous studies have discussed the presentation and outcomes of CA injury post\u2010ablation, a comprehensive review consolidating the mechanisms of CA injury following RFA remains absent in the cardiology literature. In this review, we conducted an extensive literature search spanning the past three decades to explore the link between the biophysics of RFA and CA perfusion pathophysiology, focusing on injury mechanisms. We delve into RFA lesion pathology, elucidate the mechanisms of CA injury resulting from RFA, and examine factors influencing lesion formation, such as convective cooling and the \u201cshadow effect.\u201d Furthermore, we outline methods to mitigate CA injury post\u2010RFA and propose novel research avenues to optimize lesion formation and ensure the safety of arrhythmia treatments, particularly in cases where tissue ablation is performed close to CAs.<\/jats:p>","DOI":"10.1111\/anec.70021","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T12:57:07Z","timestamp":1737550627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pathophysiological Effects on Coronary Arteries Following Radiofrequency Ablation: A Comprehensive Review"],"prefix":"10.1111","volume":"30","author":[{"given":"Syed Ali Raza","family":"Abidi","sequence":"first","affiliation":[{"name":"Department of Medicine 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