{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:48:42Z","timestamp":1765547322755,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the correlation between persistent atrial fibrillation (AF) recurrence and alterations in cystatin C levels pre\u2010 and post\u2010radiofrequency catheter ablation (RFCA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study encompassed 114 patients diagnosed with persistent AF. Their serum cystatin C levels were assessed both prior to and 3\u2009months after undergoing an RFCA procedure. The variance in cystatin C levels before and after RFCA is represented as \u0394Cystatin C. Subsequently, we compared these values between two groups: patients who did not experience a recurrence of AF (<jats:italic>n<\/jats:italic>\u2009=\u200979) and those who did experience a recurrence (<jats:italic>n<\/jats:italic>\u2009=\u200935).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant reduction in cystatin C levels post\u2010RFCA in both groups, with a more pronounced decrease observed in the non\u2010recurrence group. Moreover, the recurrence group exhibited larger left atrial diameter and volume before RFCA compared to the non\u2010recurrence group. Cox regression analysis indicated that smaller reductions in serum cystatin C levels and greater left atrial volumes before RFCA were associated with an increased risk of recurrence, after adjusting for covariates. The receiver operating characteristic curve indicated an elevated probability of clinical recurrence of AF post\u2010RFCA in patients with a cystatin C decline &lt;\u20090.08\u2009mg\/L (AUC 0.64). The Kaplan\u2013Meier survival analysis revealed that patients with a cystatin C decline &gt;\u20090.08\u2009mg\/L exhibited significantly higher rates of remaining free from recurrence following RFCA across a 24\u2010month follow\u2010up period (Log\u2010rank test <jats:italic>p<\/jats:italic>\u2009=\u20090.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Alterations in \u0394Cystatin C levels pre and post\u2010RFCA in the initial phase could independently predict the recurrence of AF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.70024","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T10:39:02Z","timestamp":1729075142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the Prognostic Significance of Cystatin C Level Variations Pre\u2010 and Post\u2010Radiofrequency Catheter Ablation in the Recurrence of Persistent Atrial Fibrillation"],"prefix":"10.1111","volume":"29","author":[{"given":"Yu\u2010Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology The Affiliated Changzhou Second People's Hospital of Nanjing Medical University  Changzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Yong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Changzhou Second People's Hospital of Nanjing Medical University  Changzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Changzhou Second People's Hospital of Nanjing Medical University  Changzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Changzhou Second People's Hospital of Nanjing Medical University  Changzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Yan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First People's Hospital of Changzhou The Third Affiliated Hospital of Soochow University  Changzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1746-7223","authenticated-orcid":false,"given":"Fang\u2010Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Changzhou Second People's Hospital of Nanjing Medical University  Changzhou Jiangsu 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