{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:21:16Z","timestamp":1783938076010,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Premature ventricular contractions (PVCs) are a frequent electrocardiographic finding in routine medical practice, and 16% of the patients with idiopathic PVCs may have underlying heart disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We analyzed the correlation between the morphology of the PVCs and the myocardial scarring identified by cardiac magnetic resonance (CMR), together with the impact of late gadolinium enhancement (LGE) on the need for ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010four patients (median age 56\u2009years) with frequent PVCs (&gt;\u2009500 PVCs on 24\u2009h) and a structurally normal heart were referred for comprehensive CMR. The patients were followed for 12\u2009months. Patients were referred for ablation if they were symptomatic in the context of frequent PVCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of LGE identified by CMR was higher among males (OR 5.506 (2.092\u201314.49) <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), with an age \u2265\u200950\u2009years (OR 1.047 (1.015\u20131.08), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and a higher PVC burden (OR 1.922 (1.723\u20131.976), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Additionally, patients with PVCs with a LBBB inferior axis had four times higher risk of exhibiting LGE (OR 4.09 (1.584\u201310.565), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In multivariate analysis, age (OR 1.059 (1.019\u20131.099), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and a LBBB inferior axis (OR 4.605 (1.472\u201314.404), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) were independently associated with the presence of LGE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with PVCs and apparently, structurally normal heart present myocardial scarring identified by CMR in 71.23% of cases. PVCs with LBBB inferior axis pattern, age \u2265\u200950\u2009years and male sex are associated with the presence of LGE on CMR. In multivariate analysis, age and LBBB inferior axis were independently correlated with the presence of LGE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.70039","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T06:55:35Z","timestamp":1732517735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictors of Myocardial Fibrosis Detected by <scp>CMR<\/scp> in Patients With Idiopathic <scp>PVCs<\/scp>"],"prefix":"10.1111","volume":"29","author":[{"given":"\u0218tefan","family":"Ailoaei","sequence":"first","affiliation":[{"name":"Department of Cardiology Institute for Cardiovascular Diseases \u201cProf. Dr. George I. M. Georgescu\u201d  Ia\u0219i Romania"},{"name":"University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d  Ia\u0219i Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren\u021biu","family":"\u0218orodoc","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d  Ia\u0219i Romania"},{"name":"Internal Medicine Clinic Emergency Clinical County Hospital \u201cSfantul Spiridon\u201d  Ia\u0219i Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1495-5062","authenticated-orcid":false,"given":"Carina","family":"Ureche","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute for Cardiovascular Diseases \u201cProf. Dr. George I. M. Georgescu\u201d  Ia\u0219i Romania"},{"name":"University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d  Ia\u0219i Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolae","family":"S\u00eetari","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute for Cardiovascular Diseases \u201cProf. Dr. George I. M. Georgescu\u201d  Ia\u0219i Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Sandu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute for Cardiovascular Diseases \u201cProf. Dr. George I. M. Georgescu\u201d  Ia\u0219i Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandr","family":"Ceasovschih","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d  Ia\u0219i Romania"},{"name":"Internal Medicine Clinic Emergency Clinical County Hospital \u201cSfantul Spiridon\u201d  Ia\u0219i Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Grecu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute for Cardiovascular Diseases \u201cProf. Dr. George I. M. Georgescu\u201d  Ia\u0219i Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu Andy","family":"Sasc\u0103u","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute for Cardiovascular Diseases \u201cProf. Dr. George I. M. Georgescu\u201d  Ia\u0219i Romania"},{"name":"University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d  Ia\u0219i Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"St\u0103tescu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute for Cardiovascular Diseases \u201cProf. Dr. George I. M. Georgescu\u201d  Ia\u0219i Romania"},{"name":"University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d  Ia\u0219i Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.14744\/AnatolJCardiol.2024.4314"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.007392"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.10.094"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12275"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.06.021"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501243120401"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-020-00607-1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2019-314922"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.042434"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000122"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.10.015"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X14666180925095923"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11101840"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006028"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11061109"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23271"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004662"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab307"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.121.009952"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.02.020"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000262"}],"container-title":["Annals of Noninvasive Electrocardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.70039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T11:59:19Z","timestamp":1732708759000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/anec.70039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/anec.70039"],"URL":"https:\/\/doi.org\/10.1111\/anec.70039","archive":["Portico"],"relation":{},"ISSN":["1082-720X","1542-474X"],"issn-type":[{"value":"1082-720X","type":"print"},{"value":"1542-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70039"}}