{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:27:37Z","timestamp":1753878457699,"version":"3.41.2"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Arterial stiffness, measured using carotid\u2010femoral pulse wave velocity (c\u2010f PWV) and heart rate\u2010corrected augmentation index (Aix75), is associated with cardiovascular disease, and in some studies incident atrial fibrillation (AF). In this cross\u2010sectional study, we aimed to investigate whether arterial stiffness is associated with markers of atrial myopathy, which refers to structural and electrical changes in the atria that indicate increased AF risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 1050 participants (age 57\u2009\u00b1\u20094.3\u2009years, 47% males) from the population\u2010based Swedish CArdioPulmonary bioImage Study with c\u2010f PWV and Aix75 data. A random subsample (<jats:italic>n<\/jats:italic>\u2009=\u2009331) underwent echocardiography. The association between arterial stiffness and atrial myopathy markers was studied using multivariable\u2010adjusted negative binomial regression models for premature atrial complexes (PACs) on 24\u2009h ECG, linear regression for P\u2010wave duration and left atrial volume index (LAVi), and logistic regression models for abnormal P\u2010wave terminal force in V1 (PWTFV1) and P\u2010wave axis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Arterial stiffness was associated with fewer PACs: incidence rate ratio (IRR) 0.45 (95% CI: 0.31 to 0.65, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) per 1\u2009m\/s increase in c\u2010f PWV and IRR 0.66 (95% CI: 0.49 to 0.89, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) per % increase in Aix75. There was no association between arterial stiffness and P\u2010wave indices, OR 1.09 (95% CI: 0.85 to 1.40), <jats:italic>p<\/jats:italic>\u2009=\u20090.50 for abnormal PWTFV1, and <jats:italic>\u03b2<\/jats:italic> \u22120.003 (\u22120.10 to 0.09), <jats:italic>p<\/jats:italic>\u2009=\u20090.95 for P\u2010wave duration, both per 1\u2009m\/s increase in c\u2010f PWV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Arterial stiffness, measured as either c\u2010f PWV or Aix75, was associated with fewer PACs, whereas no association was found with P\u2010wave indices. The association between arterial stiffness and atrial myopathy is complex and merits further study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.70044","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T12:11:56Z","timestamp":1738325516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arterial Stiffness and Markers of Atrial Myopathy"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3661-9784","authenticated-orcid":false,"given":"Magdalena","family":"Okrajni","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Malm\u00f6 Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5592-8717","authenticated-orcid":false,"given":"Pyotr","family":"Platonov","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iram Faqir","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Malm\u00f6 Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5369-1296","authenticated-orcid":false,"given":"Fredrik","family":"Holmqvist","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund Lund University  Lund Sweden"},{"name":"Department of Cardiology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3946-5529","authenticated-orcid":false,"given":"Johan Economou","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Malm\u00f6 Lund University  Malm\u00f6 Sweden"},{"name":"Department of Clinical Sciences, Lund Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Malm\u00f6 Lund University  Malm\u00f6 Sweden"},{"name":"Department of Clinical Physiology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Kennb\u00e4ck","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Malm\u00f6 Lund University  Malm\u00f6 Sweden"},{"name":"Department of Internal Medicine Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Healey","sequence":"additional","affiliation":[{"name":"Population Health Research Institute McMaster University  Hamilton Ontario Canada"},{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Engstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Malm\u00f6 Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2249-8220","authenticated-orcid":false,"given":"Linda S.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Malm\u00f6 Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1985"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000103131.70301.4F"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpt080"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.10.946"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.874982"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002000"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)95580-6"},{"issue":"500","key":"e_1_2_12_9_1","first-page":"e501","article-title":"Association of Premature Ventricular Complexes With Central Aortic Pressure Indices and Pulse Wave Velocity","volume":"155","author":"Chen J. 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