{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:49:59Z","timestamp":1789159799313,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients undergoing cardiac resynchronization therapy with a defibrillator (CRT\u2010D) often experience improvements in the left ventricular ejection fraction (LVEF). This study aimed to identify predictors of ventricular tachyarrhythmias (VTA) in patients with CRT\u2010D devices and LVEF improvement beyond guideline recommendations for a defibrillator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients randomized to the CRT\u2010D arm of the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy trial who improved their LVEF to &gt;\u200935% at 12\u2009months following CRT\u2010D implant were included in this analysis (<jats:italic>N<\/jats:italic>\u2009=\u2009651). Predictors of an appropriate implantable cardioverter defibrillator (ICD) Rx VTA were evaluated by Cox proportional hazards regression modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified three predictors of VTA among patients treated with CRT\u2010D subsequent to LVEF improvement &gt;\u200935%: Lower range improvement in LVEF 36%\u201340% versus improvement to &gt;\u200940% (HR, 1.97; 95% CI, 1.21\u20133.20; <jats:italic>p<\/jats:italic>\u2009=\u20090.006); Baseline non\u2010LBBB ECG morphology (hazard ratio [HR], 1.93; 95% confidence interval [CI], 1.23\u20133.04; <jats:italic>p<\/jats:italic>\u2009=\u20090.004); Occurrence of VTA during the first year post\u2010CRT\u2010D (HR, 4.91; 95% CI, 2.99\u20138.07; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We identified a sub\u2010group of patients with risk factors who remain at high risk of VTA despite improvement in LVEF following CRT implant. These patients require close monitoring despite improvement in LVEF beyond guideline recommendations for an ICD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.70059","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T15:29:23Z","timestamp":1744126163000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predicting Ventricular Tachyarrhythmias in Patients With Left Ventricular Ejection Fraction Improvement Following Cardiac Resynchronization Therapy"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7957-1546","authenticated-orcid":false,"given":"Adam","family":"Visca","sequence":"first","affiliation":[{"name":"Division of Cardiology, Clinical Cardiovascular Research Center, School of Medicine and Dentistry University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadia","family":"Sherazi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Clinical Cardiovascular Research Center, School of Medicine and Dentistry University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Clinical Cardiovascular Research Center, School of Medicine and Dentistry University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"McNitt","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Clinical Cardiovascular Research Center, School of Medicine and Dentistry University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhila","family":"Rao","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Clinical Cardiovascular Research Center, School of Medicine and Dentistry University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh","family":"Rao","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Clinical Cardiovascular Research Center, School of Medicine and Dentistry University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Clinical Cardiovascular Research Center, School of Medicine and Dentistry University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9003-9384","authenticated-orcid":false,"given":"Mehmet","family":"Aktas","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Clinical Cardiovascular Research Center, School of Medicine and Dentistry University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-289X","authenticated-orcid":false,"given":"Valentina","family":"Kutyifa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Clinical Cardiovascular Research Center, School of Medicine and Dentistry University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Zareba","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Clinical Cardiovascular Research Center, School of Medicine and Dentistry University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Rao","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Clinical Cardiovascular Research Center, School of Medicine and Dentistry University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2008.07.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy182"},{"issue":"3","key":"e_1_2_10_6_1","first-page":"e283","article-title":"ACCF\/AHA\/HRS Focused Update Incorporated Into the ACCF\/AHA\/HRS 2008 Guidelines for Device\u2010Based Therapy of Cardiac Rhythm Abnormalities","volume":"127","author":"Epstein A. 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