{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:43:25Z","timestamp":1763729005353,"version":"3.43.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL134885"],"award-info":[{"award-number":["HL134885"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TR002377"],"award-info":[{"award-number":["TR002377"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) imaging is a well\u2010established indicator of myocardial fibrosis in hypertrophic cardiomyopathy (HCM). However, its association with electrocardiographic (ECG) abnormalities and the risk of atrial fibrillation (AF) remains uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the association between the presence and burden of LGE with ECG characteristics, including precordial voltage, depolarization and repolarization abnormalities, and the incidence of AF in adults with HCM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study of 144 adults with HCM with CMR and 12\u2010lead ECG within 30\u2009days of each other. LGE was quantified as a percentage of LV mass and categorized as absent, &lt;\u20095%, or \u2265\u20095%. ECG parameters, including QRS voltage, repolarization abnormalities, and LVH criteria, were analyzed. Incident AF was assessed during a median follow\u2010up of 6.6\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LGE was present in 96 (67%) patients, with 21 (22%) having \u2265\u20095% LGE. There were no significant differences in precordial voltage between patients with and without LGE across Sokolow\u2010Lyon, Cornell, and Romhilt\u2010Estes criteria. However, T\u2010wave inversion was more common in leads I (41% vs. 19%, <jats:italic>p<\/jats:italic>\u2009=\u20090.009), aVL (50% vs. 31%, <jats:italic>p<\/jats:italic>\u2009=\u20090.033), and V4 (41% vs. 23%, <jats:italic>p<\/jats:italic>\u2009=\u20090.035) in patients with LGE. Patients with \u2265\u20095% LGE had a significantly lower median LVEF (64% vs. 74%, <jats:italic>p<\/jats:italic>\u2009=\u20090.003). Additionally, LGE presence was not associated with an increased risk of incident AF (HR 1.8, 95% CI 0.6\u20135.3, <jats:italic>p<\/jats:italic>\u2009=\u20090.308).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In contrast to pediatric HCM, LGE is associated with specific ECG repolarization abnormalities, particularly T\u2010wave inversion in lateral leads, but does not significantly affect precordial voltage in adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.70077","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T10:46:57Z","timestamp":1749725217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Late Gadolinium Enhancement and Electrocardiographic Associations in Hypertrophic Cardiomyopathy"],"prefix":"10.1111","volume":"30","author":[{"given":"Issa","family":"Asfour","sequence":"first","affiliation":[{"name":"East Tennessee State University  Johnson City Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0109-5809","authenticated-orcid":false,"given":"Shahid","family":"Karim","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"},{"name":"William Harvey Research Institute, Barts Biomedical Centre Queen Mary University London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sair A.","family":"Tabraiz","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7825-8827","authenticated-orcid":false,"given":"Anwar","family":"Chahal","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"},{"name":"William Harvey Research Institute, Barts Biomedical Centre Queen Mary University London  London UK"},{"name":"University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Center for Inherited Cardiovascular Diseases WellSpan Health  York PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Y.","family":"Khanji","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts Biomedical Centre Queen Mary University London  London UK"},{"name":"Barts Heart Centre, St Bartholomew's Hospital Barts Health NHS Trust  London UK"},{"name":"Newham University Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1519-3688","authenticated-orcid":false,"given":"Akil A.","family":"Sherif","sequence":"additional","affiliation":[{"name":"Saint Vincent Hospital  Worcester USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve R.","family":"Ommen","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virend K.","family":"Somers","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Lin","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Brady","sequence":"additional","affiliation":[{"name":"Advocate Illinois Masonic Medical Centre  Chicago Illinois 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