{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:54:27Z","timestamp":1754160867835,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Female LQTS patients are at high risk for arrhythmogenic events during the postpartum period due to hormonal influence on cardiac repolarization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We observed an LQT1 patient with previous cardiac events during pregnancy and 3\u2009weeks postpartum. We obtained ECG recordings and quantified sex hormone levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peak pregnancy: QTc: 420\u2009\u00b1\u20097\u2009ms, Estradiol: 24.18\u2009ng\/mL, Progesterone: 218\u2009ng\/mL. Seven days postpartum: QTc prolongation to 455\u2009\u00b1\u20095\u2009ms. 22\u2009days postpartum: QTc: 452\u2009\u00b1\u20095, Estradiol: 0.013\u2009ng\/mL, Progesterone: 0.25\u2009ng\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Estradiol and Progesterone decline rapidly after birth, correlating to QTc prolongation and elevated risk for arrhythmogenic events. Therefore, modification of pharmacological or device therapy may be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.70079","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T06:18:25Z","timestamp":1749536305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postpartum <scp>QT<\/scp> Prolongation in a Long <scp>QT<\/scp> Syndrome Type 1 Patient"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1784-3410","authenticated-orcid":false,"given":"Lilli C.","family":"Wiedenmann","sequence":"first","affiliation":[{"name":"St Josefs\u2010Hospital  Wiesbaden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim R.","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"St Josefs\u2010Hospital  Wiesbaden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center  Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1093\/eurheartj\/ehv371"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1016\/j.hrthm.2022.04.029"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1093\/europace\/euz037"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1016\/j.jacc.2008.02.068"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1016\/j.hrthm.2021.07.058"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.3390\/ijms23137389"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1016\/j.hrthm.2004.01.006"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1172\/JCI25537"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1111\/j.1540\u20108159.2006.00407.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1016\/j.hrthm.2012.01.009"},{"doi-asserted-by":"publisher","key":"e_1_2_7_12_1","DOI":"10.1001\/jama.285.10.1322"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1016\/j.jacc.2006.08.057"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.1016\/j.jacc.2006.09.054"}],"container-title":["Annals of Noninvasive Electrocardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.70079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T05:08:44Z","timestamp":1753679324000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/anec.70079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/anec.70079"],"URL":"https:\/\/doi.org\/10.1111\/anec.70079","archive":["Portico"],"relation":{},"ISSN":["1082-720X","1542-474X"],"issn-type":[{"type":"print","value":"1082-720X"},{"type":"electronic","value":"1542-474X"}],"subject":[],"published":{"date-parts":[[2025,6,10]]},"assertion":[{"value":"2025-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70079"}}